Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves

Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant ((*) P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 ...

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Autores principales: Manaharan, Thamilvaani, Thirugnanasampandan, Ramaraj, Jayakumar, Rajarajeswaran, Ramya, Gunasekar, Ramnath, Gogul, Kanthimathi, M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238170/
https://www.ncbi.nlm.nih.gov/pubmed/25431779
http://dx.doi.org/10.1155/2014/239508
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author Manaharan, Thamilvaani
Thirugnanasampandan, Ramaraj
Jayakumar, Rajarajeswaran
Ramya, Gunasekar
Ramnath, Gogul
Kanthimathi, M. S.
author_facet Manaharan, Thamilvaani
Thirugnanasampandan, Ramaraj
Jayakumar, Rajarajeswaran
Ramya, Gunasekar
Ramnath, Gogul
Kanthimathi, M. S.
author_sort Manaharan, Thamilvaani
collection PubMed
description Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant ((*) P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.
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spelling pubmed-42381702014-11-27 Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves Manaharan, Thamilvaani Thirugnanasampandan, Ramaraj Jayakumar, Rajarajeswaran Ramya, Gunasekar Ramnath, Gogul Kanthimathi, M. S. ScientificWorldJournal Research Article Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant ((*) P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer. Hindawi Publishing Corporation 2014 2014-11-05 /pmc/articles/PMC4238170/ /pubmed/25431779 http://dx.doi.org/10.1155/2014/239508 Text en Copyright © 2014 Thamilvaani Manaharan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Manaharan, Thamilvaani
Thirugnanasampandan, Ramaraj
Jayakumar, Rajarajeswaran
Ramya, Gunasekar
Ramnath, Gogul
Kanthimathi, M. S.
Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves
title Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves
title_full Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves
title_fullStr Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves
title_full_unstemmed Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves
title_short Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves
title_sort antimetastatic and anti-inflammatory potentials of essential oil from edible ocimum sanctum leaves
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238170/
https://www.ncbi.nlm.nih.gov/pubmed/25431779
http://dx.doi.org/10.1155/2014/239508
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