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Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin

Gamma radiation induces the generation of free radicals, leading to serious cellular damages in biological systems. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the deleterious effects of radiation. Melatonin synergistically acts as an immu...

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Autores principales: Mihandoost, Ehsan, Shirazi, Alireza, Mahdavi, Seied Rabie, Aliasgharzadeh, Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238234/
https://www.ncbi.nlm.nih.gov/pubmed/25431791
http://dx.doi.org/10.1155/2014/621570
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author Mihandoost, Ehsan
Shirazi, Alireza
Mahdavi, Seied Rabie
Aliasgharzadeh, Akbar
author_facet Mihandoost, Ehsan
Shirazi, Alireza
Mahdavi, Seied Rabie
Aliasgharzadeh, Akbar
author_sort Mihandoost, Ehsan
collection PubMed
description Gamma radiation induces the generation of free radicals, leading to serious cellular damages in biological systems. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the deleterious effects of radiation. Melatonin synergistically acts as an immune-stimulator and antioxidant. We investigated the possible radioprotective role of melatonin (100 mg/kg i.p.) against lethal-whole-body radiation- (10 Gy) induced sickness, body weight loss, and mortality in rats. Results of the present study suggest that exposure to lethal-whole-body radiation incurred mortality, body weight loss, and apoptosis and it also depleted the immunity and the antioxidant status of the rats. Our results show that melatonin pretreatment provides protection against radiation induced mortality, oxidative stress, and immune-suppression. The melatonin pretreated irradiated rats showed less change in body weight as compared to radiation only group. On the other hand, melatonin appeared to have another radioprotective role, suggesting that melatonin may reduce apoptosis through a caspase-3-mediated pathway by blocking caspase-3 activity.
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spelling pubmed-42382342014-11-27 Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin Mihandoost, Ehsan Shirazi, Alireza Mahdavi, Seied Rabie Aliasgharzadeh, Akbar ScientificWorldJournal Research Article Gamma radiation induces the generation of free radicals, leading to serious cellular damages in biological systems. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the deleterious effects of radiation. Melatonin synergistically acts as an immune-stimulator and antioxidant. We investigated the possible radioprotective role of melatonin (100 mg/kg i.p.) against lethal-whole-body radiation- (10 Gy) induced sickness, body weight loss, and mortality in rats. Results of the present study suggest that exposure to lethal-whole-body radiation incurred mortality, body weight loss, and apoptosis and it also depleted the immunity and the antioxidant status of the rats. Our results show that melatonin pretreatment provides protection against radiation induced mortality, oxidative stress, and immune-suppression. The melatonin pretreated irradiated rats showed less change in body weight as compared to radiation only group. On the other hand, melatonin appeared to have another radioprotective role, suggesting that melatonin may reduce apoptosis through a caspase-3-mediated pathway by blocking caspase-3 activity. Hindawi Publishing Corporation 2014 2014-11-05 /pmc/articles/PMC4238234/ /pubmed/25431791 http://dx.doi.org/10.1155/2014/621570 Text en Copyright © 2014 Ehsan Mihandoost et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mihandoost, Ehsan
Shirazi, Alireza
Mahdavi, Seied Rabie
Aliasgharzadeh, Akbar
Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin
title Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin
title_full Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin
title_fullStr Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin
title_full_unstemmed Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin
title_short Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin
title_sort consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238234/
https://www.ncbi.nlm.nih.gov/pubmed/25431791
http://dx.doi.org/10.1155/2014/621570
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