Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents

A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-fr...

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Detalles Bibliográficos
Autores principales: Bhatewara, Anjna, Jetti, Srinivasa Rao, Kadre, Tanuja, Paliwal, Pradeep, Jain, Shubha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238236/
https://www.ncbi.nlm.nih.gov/pubmed/25431669
http://dx.doi.org/10.1155/2013/197612
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author Bhatewara, Anjna
Jetti, Srinivasa Rao
Kadre, Tanuja
Paliwal, Pradeep
Jain, Shubha
author_facet Bhatewara, Anjna
Jetti, Srinivasa Rao
Kadre, Tanuja
Paliwal, Pradeep
Jain, Shubha
author_sort Bhatewara, Anjna
collection PubMed
description A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity.
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spelling pubmed-42382362014-11-27 Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents Bhatewara, Anjna Jetti, Srinivasa Rao Kadre, Tanuja Paliwal, Pradeep Jain, Shubha Int J Med Chem Research Article A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity. Hindawi Publishing Corporation 2013 2013-04-15 /pmc/articles/PMC4238236/ /pubmed/25431669 http://dx.doi.org/10.1155/2013/197612 Text en Copyright © 2013 Anjna Bhatewara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bhatewara, Anjna
Jetti, Srinivasa Rao
Kadre, Tanuja
Paliwal, Pradeep
Jain, Shubha
Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents
title Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents
title_full Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents
title_fullStr Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents
title_full_unstemmed Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents
title_short Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents
title_sort microwave-assisted synthesis and biological evaluation of dihydropyrimidinone derivatives as anti-inflammatory, antibacterial, and antifungal agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238236/
https://www.ncbi.nlm.nih.gov/pubmed/25431669
http://dx.doi.org/10.1155/2013/197612
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