Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles

The combination of cinchona-alkaloid-derived primary amine and Au(I)–phosphine catalysts allowed the selective C—H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in...

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Detalles Bibliográficos
Autores principales: Hack, Daniel, Loh, Charles C J, Hartmann, Jan M, Raabe, Gerhard, Enders, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238261/
https://www.ncbi.nlm.nih.gov/pubmed/24590817
http://dx.doi.org/10.1002/chem.201400407
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author Hack, Daniel
Loh, Charles C J
Hartmann, Jan M
Raabe, Gerhard
Enders, Dieter
author_facet Hack, Daniel
Loh, Charles C J
Hartmann, Jan M
Raabe, Gerhard
Enders, Dieter
author_sort Hack, Daniel
collection PubMed
description The combination of cinchona-alkaloid-derived primary amine and Au(I)–phosphine catalysts allowed the selective C—H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities.
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spelling pubmed-42382612014-11-20 Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles Hack, Daniel Loh, Charles C J Hartmann, Jan M Raabe, Gerhard Enders, Dieter Chemistry Communications The combination of cinchona-alkaloid-derived primary amine and Au(I)–phosphine catalysts allowed the selective C—H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities. WILEY-VCH Verlag 2014-04-01 2014-03-03 /pmc/articles/PMC4238261/ /pubmed/24590817 http://dx.doi.org/10.1002/chem.201400407 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Hack, Daniel
Loh, Charles C J
Hartmann, Jan M
Raabe, Gerhard
Enders, Dieter
Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles
title Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles
title_full Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles
title_fullStr Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles
title_full_unstemmed Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles
title_short Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles
title_sort merging gold and organocatalysis: a facile asymmetric synthesis of annulated pyrroles
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238261/
https://www.ncbi.nlm.nih.gov/pubmed/24590817
http://dx.doi.org/10.1002/chem.201400407
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