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Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
The development of a wide array of molecular and neuroscientific biomarkers can provide the possibility to visualize the course of Alzheimer’s disease (AD) at early stages. Many of these biomarkers are aimed at detecting not only a preclinical, but also a pre-symptomatic state. They are supposed to...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238325/ https://www.ncbi.nlm.nih.gov/pubmed/25477802 http://dx.doi.org/10.3389/fnhum.2014.00921 |
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author | Schicktanz, Silke Schweda, Mark Ballenger, Jesse F. Fox, Patrick J. Halpern, Jodi Kramer, Joel H. Micco, Guy Post, Stephen G. Thompson, Charis Knight, Robert T. Jagust, William J. |
author_facet | Schicktanz, Silke Schweda, Mark Ballenger, Jesse F. Fox, Patrick J. Halpern, Jodi Kramer, Joel H. Micco, Guy Post, Stephen G. Thompson, Charis Knight, Robert T. Jagust, William J. |
author_sort | Schicktanz, Silke |
collection | PubMed |
description | The development of a wide array of molecular and neuroscientific biomarkers can provide the possibility to visualize the course of Alzheimer’s disease (AD) at early stages. Many of these biomarkers are aimed at detecting not only a preclinical, but also a pre-symptomatic state. They are supposed to facilitate clinical trials aiming at treatments that attack the disease at its earliest stage or even prevent it. The increasing number of such biomarkers currently tested and now partly proposed for clinical implementation calls for critical reflection on their aims, social benefits, and risks. This position paper summarizes major challenges and responsibilities. Its focus is on the ethical and social problems involved in the organization and application of dementia research, as well as in healthcare provision from a cross-national point of view. The paper is based on a discussion of leading dementia experts from neuroscience, neurology, social sciences, and bioethics in the United States and Europe. It thus reflects a notable consensus across various disciplines and national backgrounds. We intend to initiate a debate on the need for actions within the researchers’ national and international communities. |
format | Online Article Text |
id | pubmed-4238325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42383252014-12-04 Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction Schicktanz, Silke Schweda, Mark Ballenger, Jesse F. Fox, Patrick J. Halpern, Jodi Kramer, Joel H. Micco, Guy Post, Stephen G. Thompson, Charis Knight, Robert T. Jagust, William J. Front Hum Neurosci Neuroscience The development of a wide array of molecular and neuroscientific biomarkers can provide the possibility to visualize the course of Alzheimer’s disease (AD) at early stages. Many of these biomarkers are aimed at detecting not only a preclinical, but also a pre-symptomatic state. They are supposed to facilitate clinical trials aiming at treatments that attack the disease at its earliest stage or even prevent it. The increasing number of such biomarkers currently tested and now partly proposed for clinical implementation calls for critical reflection on their aims, social benefits, and risks. This position paper summarizes major challenges and responsibilities. Its focus is on the ethical and social problems involved in the organization and application of dementia research, as well as in healthcare provision from a cross-national point of view. The paper is based on a discussion of leading dementia experts from neuroscience, neurology, social sciences, and bioethics in the United States and Europe. It thus reflects a notable consensus across various disciplines and national backgrounds. We intend to initiate a debate on the need for actions within the researchers’ national and international communities. Frontiers Media S.A. 2014-11-20 /pmc/articles/PMC4238325/ /pubmed/25477802 http://dx.doi.org/10.3389/fnhum.2014.00921 Text en Copyright © 2014 Schicktanz, Schweda, Ballenger, Fox, Halpern, Kramer, Micco, Post, Thompson, Knight and Jagust. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Schicktanz, Silke Schweda, Mark Ballenger, Jesse F. Fox, Patrick J. Halpern, Jodi Kramer, Joel H. Micco, Guy Post, Stephen G. Thompson, Charis Knight, Robert T. Jagust, William J. Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction |
title | Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction |
title_full | Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction |
title_fullStr | Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction |
title_full_unstemmed | Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction |
title_short | Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction |
title_sort | before it is too late: professional responsibilities in late-onset alzheimer’s research and pre-symptomatic prediction |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238325/ https://www.ncbi.nlm.nih.gov/pubmed/25477802 http://dx.doi.org/10.3389/fnhum.2014.00921 |
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