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Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction

The development of a wide array of molecular and neuroscientific biomarkers can provide the possibility to visualize the course of Alzheimer’s disease (AD) at early stages. Many of these biomarkers are aimed at detecting not only a preclinical, but also a pre-symptomatic state. They are supposed to...

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Autores principales: Schicktanz, Silke, Schweda, Mark, Ballenger, Jesse F., Fox, Patrick J., Halpern, Jodi, Kramer, Joel H., Micco, Guy, Post, Stephen G., Thompson, Charis, Knight, Robert T., Jagust, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238325/
https://www.ncbi.nlm.nih.gov/pubmed/25477802
http://dx.doi.org/10.3389/fnhum.2014.00921
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author Schicktanz, Silke
Schweda, Mark
Ballenger, Jesse F.
Fox, Patrick J.
Halpern, Jodi
Kramer, Joel H.
Micco, Guy
Post, Stephen G.
Thompson, Charis
Knight, Robert T.
Jagust, William J.
author_facet Schicktanz, Silke
Schweda, Mark
Ballenger, Jesse F.
Fox, Patrick J.
Halpern, Jodi
Kramer, Joel H.
Micco, Guy
Post, Stephen G.
Thompson, Charis
Knight, Robert T.
Jagust, William J.
author_sort Schicktanz, Silke
collection PubMed
description The development of a wide array of molecular and neuroscientific biomarkers can provide the possibility to visualize the course of Alzheimer’s disease (AD) at early stages. Many of these biomarkers are aimed at detecting not only a preclinical, but also a pre-symptomatic state. They are supposed to facilitate clinical trials aiming at treatments that attack the disease at its earliest stage or even prevent it. The increasing number of such biomarkers currently tested and now partly proposed for clinical implementation calls for critical reflection on their aims, social benefits, and risks. This position paper summarizes major challenges and responsibilities. Its focus is on the ethical and social problems involved in the organization and application of dementia research, as well as in healthcare provision from a cross-national point of view. The paper is based on a discussion of leading dementia experts from neuroscience, neurology, social sciences, and bioethics in the United States and Europe. It thus reflects a notable consensus across various disciplines and national backgrounds. We intend to initiate a debate on the need for actions within the researchers’ national and international communities.
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spelling pubmed-42383252014-12-04 Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction Schicktanz, Silke Schweda, Mark Ballenger, Jesse F. Fox, Patrick J. Halpern, Jodi Kramer, Joel H. Micco, Guy Post, Stephen G. Thompson, Charis Knight, Robert T. Jagust, William J. Front Hum Neurosci Neuroscience The development of a wide array of molecular and neuroscientific biomarkers can provide the possibility to visualize the course of Alzheimer’s disease (AD) at early stages. Many of these biomarkers are aimed at detecting not only a preclinical, but also a pre-symptomatic state. They are supposed to facilitate clinical trials aiming at treatments that attack the disease at its earliest stage or even prevent it. The increasing number of such biomarkers currently tested and now partly proposed for clinical implementation calls for critical reflection on their aims, social benefits, and risks. This position paper summarizes major challenges and responsibilities. Its focus is on the ethical and social problems involved in the organization and application of dementia research, as well as in healthcare provision from a cross-national point of view. The paper is based on a discussion of leading dementia experts from neuroscience, neurology, social sciences, and bioethics in the United States and Europe. It thus reflects a notable consensus across various disciplines and national backgrounds. We intend to initiate a debate on the need for actions within the researchers’ national and international communities. Frontiers Media S.A. 2014-11-20 /pmc/articles/PMC4238325/ /pubmed/25477802 http://dx.doi.org/10.3389/fnhum.2014.00921 Text en Copyright © 2014 Schicktanz, Schweda, Ballenger, Fox, Halpern, Kramer, Micco, Post, Thompson, Knight and Jagust. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Schicktanz, Silke
Schweda, Mark
Ballenger, Jesse F.
Fox, Patrick J.
Halpern, Jodi
Kramer, Joel H.
Micco, Guy
Post, Stephen G.
Thompson, Charis
Knight, Robert T.
Jagust, William J.
Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
title Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
title_full Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
title_fullStr Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
title_full_unstemmed Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
title_short Before it is too late: professional responsibilities in late-onset Alzheimer’s research and pre-symptomatic prediction
title_sort before it is too late: professional responsibilities in late-onset alzheimer’s research and pre-symptomatic prediction
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238325/
https://www.ncbi.nlm.nih.gov/pubmed/25477802
http://dx.doi.org/10.3389/fnhum.2014.00921
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