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Circular RNAs: diversity of form and function
It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5′ and 3′ ends of linear RNAs, as intermediates in RNA processing reactions, or by “backsplicing,” wherein a downstream 5′ splice site (splice donor) is joined to...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238349/ https://www.ncbi.nlm.nih.gov/pubmed/25404635 http://dx.doi.org/10.1261/rna.047126.114 |
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author | Lasda, Erika Parker, Roy |
author_facet | Lasda, Erika Parker, Roy |
author_sort | Lasda, Erika |
collection | PubMed |
description | It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5′ and 3′ ends of linear RNAs, as intermediates in RNA processing reactions, or by “backsplicing,” wherein a downstream 5′ splice site (splice donor) is joined to an upstream 3′ splice site (splice acceptor). Circular RNAs have unique properties including the potential for rolling circle amplification of RNA, the ability to rearrange the order of genomic information, protection from exonucleases, and constraints on RNA folding. Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Herein, we review the breadth of circular RNAs, their biogenesis and metabolism, and their known and anticipated functions. |
format | Online Article Text |
id | pubmed-4238349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42383492015-12-01 Circular RNAs: diversity of form and function Lasda, Erika Parker, Roy RNA Review It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5′ and 3′ ends of linear RNAs, as intermediates in RNA processing reactions, or by “backsplicing,” wherein a downstream 5′ splice site (splice donor) is joined to an upstream 3′ splice site (splice acceptor). Circular RNAs have unique properties including the potential for rolling circle amplification of RNA, the ability to rearrange the order of genomic information, protection from exonucleases, and constraints on RNA folding. Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Herein, we review the breadth of circular RNAs, their biogenesis and metabolism, and their known and anticipated functions. Cold Spring Harbor Laboratory Press 2014-12 /pmc/articles/PMC4238349/ /pubmed/25404635 http://dx.doi.org/10.1261/rna.047126.114 Text en © 2014 Lasda and Parker; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Lasda, Erika Parker, Roy Circular RNAs: diversity of form and function |
title | Circular RNAs: diversity of form and function |
title_full | Circular RNAs: diversity of form and function |
title_fullStr | Circular RNAs: diversity of form and function |
title_full_unstemmed | Circular RNAs: diversity of form and function |
title_short | Circular RNAs: diversity of form and function |
title_sort | circular rnas: diversity of form and function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238349/ https://www.ncbi.nlm.nih.gov/pubmed/25404635 http://dx.doi.org/10.1261/rna.047126.114 |
work_keys_str_mv | AT lasdaerika circularrnasdiversityofformandfunction AT parkerroy circularrnasdiversityofformandfunction |