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Circular RNAs: diversity of form and function

It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5′ and 3′ ends of linear RNAs, as intermediates in RNA processing reactions, or by “backsplicing,” wherein a downstream 5′ splice site (splice donor) is joined to...

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Detalles Bibliográficos
Autores principales: Lasda, Erika, Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238349/
https://www.ncbi.nlm.nih.gov/pubmed/25404635
http://dx.doi.org/10.1261/rna.047126.114
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author Lasda, Erika
Parker, Roy
author_facet Lasda, Erika
Parker, Roy
author_sort Lasda, Erika
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description It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5′ and 3′ ends of linear RNAs, as intermediates in RNA processing reactions, or by “backsplicing,” wherein a downstream 5′ splice site (splice donor) is joined to an upstream 3′ splice site (splice acceptor). Circular RNAs have unique properties including the potential for rolling circle amplification of RNA, the ability to rearrange the order of genomic information, protection from exonucleases, and constraints on RNA folding. Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Herein, we review the breadth of circular RNAs, their biogenesis and metabolism, and their known and anticipated functions.
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spelling pubmed-42383492015-12-01 Circular RNAs: diversity of form and function Lasda, Erika Parker, Roy RNA Review It is now clear that there is a diversity of circular RNAs in biological systems. Circular RNAs can be produced by the direct ligation of 5′ and 3′ ends of linear RNAs, as intermediates in RNA processing reactions, or by “backsplicing,” wherein a downstream 5′ splice site (splice donor) is joined to an upstream 3′ splice site (splice acceptor). Circular RNAs have unique properties including the potential for rolling circle amplification of RNA, the ability to rearrange the order of genomic information, protection from exonucleases, and constraints on RNA folding. Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Herein, we review the breadth of circular RNAs, their biogenesis and metabolism, and their known and anticipated functions. Cold Spring Harbor Laboratory Press 2014-12 /pmc/articles/PMC4238349/ /pubmed/25404635 http://dx.doi.org/10.1261/rna.047126.114 Text en © 2014 Lasda and Parker; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Lasda, Erika
Parker, Roy
Circular RNAs: diversity of form and function
title Circular RNAs: diversity of form and function
title_full Circular RNAs: diversity of form and function
title_fullStr Circular RNAs: diversity of form and function
title_full_unstemmed Circular RNAs: diversity of form and function
title_short Circular RNAs: diversity of form and function
title_sort circular rnas: diversity of form and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238349/
https://www.ncbi.nlm.nih.gov/pubmed/25404635
http://dx.doi.org/10.1261/rna.047126.114
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