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Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus

BACKGROUND: The clinical impact of a tumor thrombus in renal cell carcinoma (RCC) patients awaiting radical nephrectomy and thrombectomy is unknown. OBJECTIVE: To determine the incidence of venous thromboembolism (VTE) in RCC patients with tumor thrombus prior to nephrectomy. PATIENTS AND METHODS: W...

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Autores principales: Yokom, D W, Ihaddadene, R, Moretto, P, Canil, C M, Reaume, N, Le Gal, G, Carrier, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238732/
https://www.ncbi.nlm.nih.gov/pubmed/24283651
http://dx.doi.org/10.1111/jth.12459
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author Yokom, D W
Ihaddadene, R
Moretto, P
Canil, C M
Reaume, N
Le Gal, G
Carrier, M
author_facet Yokom, D W
Ihaddadene, R
Moretto, P
Canil, C M
Reaume, N
Le Gal, G
Carrier, M
author_sort Yokom, D W
collection PubMed
description BACKGROUND: The clinical impact of a tumor thrombus in renal cell carcinoma (RCC) patients awaiting radical nephrectomy and thrombectomy is unknown. OBJECTIVE: To determine the incidence of venous thromboembolism (VTE) in RCC patients with tumor thrombus prior to nephrectomy. PATIENTS AND METHODS: We conducted a retrospective cohort study including all late-stage (stage 3–4 excluding T1–2 N0M0) RCC patients who underwent radical nephrectomy at our institution between 1 January 2005 and 1 July 2012. Tumor thrombus was defined as the presence of an intraluminal filling defect in the renal vein, hepatic vein, portal vein, or inferior vena cava, directly extending from a renal mass detected on computed tomography. RESULTS: A total of 176 patients were included in the study. Fifty-three (30.1%) patients had tumor thrombus diagnosed on imaging Three patients with tumor thrombus (5.7%; 95% confidence interval [CI] 1.4–16.8) developed a VTE while awaiting radical nephrectomy, whereas none (0%; 95% CI 0–2.9) of the patients without a tumor thrombus had an event (P = 0.026). All three events were deep vein thrombosis. Times from tumor thrombus diagnosis to VTE were 5, 15 and 21 days. CONCLUSIONS: Tumor thrombus on imaging is a frequent finding among RCC patients awaiting nephrectomy. The presence of tumor thrombus in these patients increases the incidence of preoperative VTE.
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spelling pubmed-42387322014-11-28 Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus Yokom, D W Ihaddadene, R Moretto, P Canil, C M Reaume, N Le Gal, G Carrier, M J Thromb Haemost Clinical Haemostasis and Thrombosis BACKGROUND: The clinical impact of a tumor thrombus in renal cell carcinoma (RCC) patients awaiting radical nephrectomy and thrombectomy is unknown. OBJECTIVE: To determine the incidence of venous thromboembolism (VTE) in RCC patients with tumor thrombus prior to nephrectomy. PATIENTS AND METHODS: We conducted a retrospective cohort study including all late-stage (stage 3–4 excluding T1–2 N0M0) RCC patients who underwent radical nephrectomy at our institution between 1 January 2005 and 1 July 2012. Tumor thrombus was defined as the presence of an intraluminal filling defect in the renal vein, hepatic vein, portal vein, or inferior vena cava, directly extending from a renal mass detected on computed tomography. RESULTS: A total of 176 patients were included in the study. Fifty-three (30.1%) patients had tumor thrombus diagnosed on imaging Three patients with tumor thrombus (5.7%; 95% confidence interval [CI] 1.4–16.8) developed a VTE while awaiting radical nephrectomy, whereas none (0%; 95% CI 0–2.9) of the patients without a tumor thrombus had an event (P = 0.026). All three events were deep vein thrombosis. Times from tumor thrombus diagnosis to VTE were 5, 15 and 21 days. CONCLUSIONS: Tumor thrombus on imaging is a frequent finding among RCC patients awaiting nephrectomy. The presence of tumor thrombus in these patients increases the incidence of preoperative VTE. BlackWell Publishing Ltd 2014-02 2014-02-07 /pmc/articles/PMC4238732/ /pubmed/24283651 http://dx.doi.org/10.1111/jth.12459 Text en © 2013 The Authors Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Clinical Haemostasis and Thrombosis
Yokom, D W
Ihaddadene, R
Moretto, P
Canil, C M
Reaume, N
Le Gal, G
Carrier, M
Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus
title Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus
title_full Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus
title_fullStr Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus
title_full_unstemmed Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus
title_short Increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus
title_sort increased risk of preoperative venous thromboembolism in patients with renal cell carcinoma and tumor thrombus
topic Clinical Haemostasis and Thrombosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238732/
https://www.ncbi.nlm.nih.gov/pubmed/24283651
http://dx.doi.org/10.1111/jth.12459
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