Cargando…
High prevalence of occult hepatitis B virus genotype H infection among children with clinical hepatitis in west Mexico
Studies on the prevalence of infection with hepatitis B virus (HBV) among children are scarce in Latin American countries, especially in Mexico. This study was aimed to investigate the prevalence of HBV infection, occult hepatitis B infection (OBI) and HBV genotypes among children with clinical hepa...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238764/ https://www.ncbi.nlm.nih.gov/pubmed/25099333 http://dx.doi.org/10.1590/0074-0276140058 |
_version_ | 1782345508862296064 |
---|---|
author | Escobedo-Melendez, Griselda Panduro, Arturo Fierro, Nora A Roman, Sonia |
author_facet | Escobedo-Melendez, Griselda Panduro, Arturo Fierro, Nora A Roman, Sonia |
author_sort | Escobedo-Melendez, Griselda |
collection | PubMed |
description | Studies on the prevalence of infection with hepatitis B virus (HBV) among children are scarce in Latin American countries, especially in Mexico. This study was aimed to investigate the prevalence of HBV infection, occult hepatitis B infection (OBI) and HBV genotypes among children with clinical hepatitis. In total, 215 children with clinical hepatitis were evaluated for HBV infection. HBV serological markers and HBV DNA were analysed. OBI diagnosis and HBV genotyping was performed. HBV infection was found in 11.2% of children with clinical hepatitis. Among these HBV DNA positive-infected children, OBI was identified in 87.5% (n = 21/24) of the cases and 12.5% (n = 3/24) were positive for both HBV DNA and hepatitis B surface antigen. OBI was more frequent among children who had not been vaccinated against hepatitis B (p < 0.05) than in those who had been vaccinated. HBV genotype H was prevalent in 71% of the children followed by genotype G (8%) and genotype A (4%). In conclusion, OBI is common among Mexican children with clinical hepatitis and is associated with HBV genotype H. The results show the importance of the molecular diagnosis of HBV infection in Mexican paediatric patients with clinical hepatitis and emphasise the necessity of reinforcing hepatitis B vaccination in children. |
format | Online Article Text |
id | pubmed-4238764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-42387642014-11-26 High prevalence of occult hepatitis B virus genotype H infection among children with clinical hepatitis in west Mexico Escobedo-Melendez, Griselda Panduro, Arturo Fierro, Nora A Roman, Sonia Mem Inst Oswaldo Cruz Articles Studies on the prevalence of infection with hepatitis B virus (HBV) among children are scarce in Latin American countries, especially in Mexico. This study was aimed to investigate the prevalence of HBV infection, occult hepatitis B infection (OBI) and HBV genotypes among children with clinical hepatitis. In total, 215 children with clinical hepatitis were evaluated for HBV infection. HBV serological markers and HBV DNA were analysed. OBI diagnosis and HBV genotyping was performed. HBV infection was found in 11.2% of children with clinical hepatitis. Among these HBV DNA positive-infected children, OBI was identified in 87.5% (n = 21/24) of the cases and 12.5% (n = 3/24) were positive for both HBV DNA and hepatitis B surface antigen. OBI was more frequent among children who had not been vaccinated against hepatitis B (p < 0.05) than in those who had been vaccinated. HBV genotype H was prevalent in 71% of the children followed by genotype G (8%) and genotype A (4%). In conclusion, OBI is common among Mexican children with clinical hepatitis and is associated with HBV genotype H. The results show the importance of the molecular diagnosis of HBV infection in Mexican paediatric patients with clinical hepatitis and emphasise the necessity of reinforcing hepatitis B vaccination in children. Instituto Oswaldo Cruz, Ministério da Saúde 2014-09 /pmc/articles/PMC4238764/ /pubmed/25099333 http://dx.doi.org/10.1590/0074-0276140058 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Escobedo-Melendez, Griselda Panduro, Arturo Fierro, Nora A Roman, Sonia High prevalence of occult hepatitis B virus genotype H infection among children with clinical hepatitis in west Mexico |
title | High prevalence of occult hepatitis B virus genotype H
infection among children with clinical hepatitis in west Mexico |
title_full | High prevalence of occult hepatitis B virus genotype H
infection among children with clinical hepatitis in west Mexico |
title_fullStr | High prevalence of occult hepatitis B virus genotype H
infection among children with clinical hepatitis in west Mexico |
title_full_unstemmed | High prevalence of occult hepatitis B virus genotype H
infection among children with clinical hepatitis in west Mexico |
title_short | High prevalence of occult hepatitis B virus genotype H
infection among children with clinical hepatitis in west Mexico |
title_sort | high prevalence of occult hepatitis b virus genotype h
infection among children with clinical hepatitis in west mexico |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238764/ https://www.ncbi.nlm.nih.gov/pubmed/25099333 http://dx.doi.org/10.1590/0074-0276140058 |
work_keys_str_mv | AT escobedomelendezgriselda highprevalenceofocculthepatitisbvirusgenotypehinfectionamongchildrenwithclinicalhepatitisinwestmexico AT panduroarturo highprevalenceofocculthepatitisbvirusgenotypehinfectionamongchildrenwithclinicalhepatitisinwestmexico AT fierronoraa highprevalenceofocculthepatitisbvirusgenotypehinfectionamongchildrenwithclinicalhepatitisinwestmexico AT romansonia highprevalenceofocculthepatitisbvirusgenotypehinfectionamongchildrenwithclinicalhepatitisinwestmexico |