Cargando…

Direct Measurement of Lipase Inhibition by Orlistat Using a Dissolution Linked In Vitro Assay

PURPOSE: To develop a bio-assay that would be able to directly test gastrointestinal and/or dissolution samples to determine lipase activity and inhibition by Orlistat. METHODS: Enzyme assays were performed with porcine pancreatic lipase and para-Nitrophenyl Palmitate (pNPP) in pH 8.0 reaction buffe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lewis, Daniel R, Liu, Dongzhou J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238884/ https://www.ncbi.nlm.nih.gov/pubmed/25419492 http://dx.doi.org/10.4172/2167-065X.1000103

Ejemplares similares

The Use of Orlistat in an Adult with Lipoprotein Lipase Deficiency: A Case Report
por: Jarrett, Zachary S., et al.
Publicado: (2021)

PPARγ as a sensor of lipase activity and a target for the lipase inhibitor orlistat
por: Martin, Harry, et al.
Publicado: (2013)

Orlistat-loaded solid SNEDDS for the enhanced solubility, dissolution, and in vivo performance
por: Kim, Dae Hun, et al.
Publicado: (2018)

Selection of orlistat as a potential inhibitor for lipase from Candida species
por: Khedidja, Benarous, et al.
Publicado: (2011)

Refsum's Disease—Use of the Intestinal Lipase Inhibitor, Orlistat, as a Novel Therapeutic Approach to a Complex Disorder
por: Perera, Nimalie J., et al.
Publicado: (2011)

Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat
por: Kitadokoro, Kengo, et al.
Publicado: (2020)

Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model
por: Javed, Mavra, et al.
Publicado: (2023)

High Sensitivity of Giardia duodenalis to Tetrahydrolipstatin (Orlistat) In Vitro
por: Hahn, Juliane, et al.
Publicado: (2013)

Comparison of orlistat and orlistat plus metformin therapy between diabetic and nondiabetic groups
por: Gunay, Yasemin Emur, et al.
Publicado: (2023)

Obesity management: Update on orlistat
por: Drew, Belinda S, et al.
Publicado: (2007)

Anti-Lipase Potential of the Organic and Aqueous Extracts of Ten Traditional Edible and Medicinal Plants in Palestine; a Comparison Study with Orlistat
por: Jaradat, Nidal, et al.
Publicado: (2017)

Reduction of Excessive Visceral Fat and Safety with 52-Week Administration of Lipase Inhibitor Orlistat in Japanese: Long-Term Clinical Study
por: Shirai, Kohji, et al.
Publicado: (2018)

Inhibition of CpLIP2 Lipase Hydrolytic Activity by Four Flavonols (Galangin, Kaempferol, Quercetin, Myricetin) Compared to Orlistat and Their Binding Mechanisms Studied by Quenching of Fluorescence
por: Nasri, Ruba, et al.
Publicado: (2019)

Orlistat in the prevention of diabetes in the obese patient
por: Mancini, Marcio C, et al.
Publicado: (2008)

Macrocytic Anemia and Thrombocytopenia Induced by Orlistat
por: Palacios-Martinez, David, et al.
Publicado: (2013)

Acute oxalate nephropathy associated with orlistat
por: Humayun, Youshay, et al.
Publicado: (2016)

Efficacy and Safety of Lipase Inhibitor Orlistat in Japanese with Excessive Visceral Fat Accumulation: 24-Week, Double-Blind, Randomized, Placebo-Controlled Study
por: Shirai, Kohji, et al.
Publicado: (2018)

Evaluation of efficacy and safety of orlistat in obese patients
por: Jain, Suyog S., et al.
Publicado: (2011)

The Effect of Orlistat on Sterol Metabolism in Obese Patients
por: Kwon, Yu-Jin, et al.
Publicado: (2022)

Orlistat-Induced Gut Microbiota Modification in Obese Mice
por: Ke, Jing, et al.
Publicado: (2020)

Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase
por: Fako, Valerie E., et al.
Publicado: (2014)

The Application of Quantitative (1)H-NMR for the Determination of Orlistat in Tablets
por: Sun, Shanshan, et al.
Publicado: (2017)

A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity
por: Menden, Ariane, et al.
Publicado: (2019)

Clinical and economic considerations of antiobesity treatment: a review of orlistat
por: Zohrabian, Armineh
Publicado: (2010)

Taking Orlistat: Predicting Weight Loss over 6 Months
por: Hollywood, Amelia, et al.
Publicado: (2011)

An Unexpected Result of Obesity Treatment: Orlistat-Related Acute Pancreatitis
por: Kose, Murat, et al.
Publicado: (2015)

The effect of orlistat and weight loss diet on plasma ghrelin and obestatin
por: Pamuk, Baris, et al.
Publicado: (2018)

Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
por: Hao, Xiaoqing, et al.
Publicado: (2023)

Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats
por: Othman, Zaidatul Akmal, et al.
Publicado: (2022)

Improved Formazan Dissolution for Bacterial MTT Assay
por: Benov, Ludmil
Publicado: (2021)

Study of Analytical Error in Lipase Assay
por: Kumari, Sweta, et al.
Publicado: (2023)

Risk of colorectal cancer after initiation of orlistat: matched cohort study
por: Hong, Jin-Liern, et al.
Publicado: (2013)

Comparision of Efficacy and Safety of Orlistat vs Placebo in Obese Patients in Pakistan
por: Syed, Asghar Hussain, et al.
Publicado: (2020)

Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway
por: Ye, Mujie, et al.
Publicado: (2023)

A novel live cell assay to measure diacylglycerol lipase α activity
por: Singh, Praveen K., et al.
Publicado: (2016)

Effect of preconceptional orlistat treatment on in-vitro fertilization outcome in overweight/obese women: study protocol for a randomized controlled trial
por: Li, Jing, et al.
Publicado: (2018)

Reversible Serum Carcinoembriogenic Antigen (CEA) Elevation Due to Orlistat Use: A Case Report
por: dos Santos Fernandes, Gustavo, et al.
Publicado: (2010)

Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood
por: Lorenson, Mary Y, et al.
Publicado: (2019)

Lipase inhibitory activity assay for fermented milk
por: Gil-Rodríguez, Ana María, et al.
Publicado: (2020)

Measurement of feline lipase activity using a dry-chemistry assay with a triolein substrate and comparison with pancreas-specific lipase (Spec fPL(TM))
por: OISHI, Mariko, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ff3nt6ua59jeen6k23cl5p8amm