Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders

Misfolded proteins (MP) are a key component in aging and associated neurodegenerative disorders. For example, misfolded Amyloid-ß (Aß) and tau proteins are two neuropathogenic hallmarks of Alzheimer's disease. Mechanisms underlying intra-brain MP propagation/deposition remain essentially unchar...

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Detalles Bibliográficos
Autores principales: Iturria-Medina, Yasser, Sotero, Roberto C., Toussaint, Paule J., Evans, Alan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238950/
https://www.ncbi.nlm.nih.gov/pubmed/25412207
http://dx.doi.org/10.1371/journal.pcbi.1003956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238950/
https://www.ncbi.nlm.nih.gov/pubmed/25412207
http://dx.doi.org/10.1371/journal.pcbi.1003956

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