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Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders

Misfolded proteins (MP) are a key component in aging and associated neurodegenerative disorders. For example, misfolded Amyloid-ß (Aß) and tau proteins are two neuropathogenic hallmarks of Alzheimer's disease. Mechanisms underlying intra-brain MP propagation/deposition remain essentially unchar...

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Detalles Bibliográficos
Autores principales:	Iturria-Medina, Yasser, Sotero, Roberto C., Toussaint, Paule J., Evans, Alan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238950/ https://www.ncbi.nlm.nih.gov/pubmed/25412207 http://dx.doi.org/10.1371/journal.pcbi.1003956

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