Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions

PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune signaling pathways. Consequently, viruses have...

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Detalles Bibliográficos
Autores principales: Scherer, Myriam, Klingl, Stefan, Sevvana, Madhumati, Otto, Victoria, Schilling, Eva-Maria, Stump, Joachim D., Müller, Regina, Reuter, Nina, Sticht, Heinrich, Muller, Yves A., Stamminger, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239116/
https://www.ncbi.nlm.nih.gov/pubmed/25412268
http://dx.doi.org/10.1371/journal.ppat.1004512

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