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Activation of calcineurin underlies altered trafficking of α2 subunit containing GABA(A) receptors during prolonged epileptiform activity

Fast inhibitory signalling in the mammalian brain is mediated by gamma-aminobutyric acid type A receptors (GABA(A)Rs), which are targets for anti-epileptic therapy such as benzodiazepines. GABA(A)Rs undergo tightly regulated trafficking processes that are essential for maintenance and physiological...

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Detalles Bibliográficos
Autores principales:	Eckel, Ramona, Szulc, Blanka, Walker, Matthew C., Kittler, Josef T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239296/ https://www.ncbi.nlm.nih.gov/pubmed/25245802 http://dx.doi.org/10.1016/j.neuropharm.2014.09.014

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