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Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model

BACKGROUND: For long, natural killer (NK) cells have been suspected to play a critical role in suppressing the development of spontaneous metastases in cancer patients. Despite a wide range of studies it remains unclear so far to what extent primary tumor growth together with formation of distant me...

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Detalles Bibliográficos
Autores principales:	Brodbeck, Tobias, Nehmann, Nina, Bethge, Anja, Wedemann, Gero, Schumacher, Udo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239380/ https://www.ncbi.nlm.nih.gov/pubmed/25373310 http://dx.doi.org/10.1186/1476-4598-13-244

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