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Forkhead Transcription Factor FOXO3a Levels Are Increased in Huntington Disease Because of Overactivated Positive Autofeedback Loop

Huntington disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by an increased number of CAG repeats in the HTT gene coding for huntingtin. Decreased neurotrophic support and increased mitochondrial and excitotoxic stress have been reported in HD striatal and cortical neuron...

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Detalles Bibliográficos
Autores principales:	Kannike, Kaja, Sepp, Mari, Zuccato, Chiara, Cattaneo, Elena, Timmusk, Tõnis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239633/ https://www.ncbi.nlm.nih.gov/pubmed/25271153 http://dx.doi.org/10.1074/jbc.M114.612424

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