Cargando…
SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014
GEP-NENs are a challenging family of tumors of growing incidence and varied clinical management and behavior. Diagnostic techniques have substantially improved over the past decades and significant advances have been achieved in the understanding of the molecular pathways governing tumor initiation...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239790/ https://www.ncbi.nlm.nih.gov/pubmed/25183048 http://dx.doi.org/10.1007/s12094-014-1214-6 |
_version_ | 1782345642070245376 |
---|---|
author | Garcia-Carbonero, R. JImenez-Fonseca, P. Teulé, A. Barriuso, J. Sevilla, I. |
author_facet | Garcia-Carbonero, R. JImenez-Fonseca, P. Teulé, A. Barriuso, J. Sevilla, I. |
author_sort | Garcia-Carbonero, R. |
collection | PubMed |
description | GEP-NENs are a challenging family of tumors of growing incidence and varied clinical management and behavior. Diagnostic techniques have substantially improved over the past decades and significant advances have been achieved in the understanding of the molecular pathways governing tumor initiation and progression. This has already translated into relevant advances in the clinic. This guideline aims to provide practical recommendations for the diagnosis and treatment of GEP-NENs. Diagnostic workup, histological and staging classifications, and the different available therapeutic approaches, including surgery, liver-directed ablative therapies, peptide receptor radionuclide therapy, and systemic hormonal, cytotoxic or targeted therapy, are briefly discussed in this manuscript. Clinical presentation (performance status, comorbidities, tumor-derived symptoms and hormone syndrome in functioning tumors), histological features [tumor differentiation, proliferation rate (Ki-67), and expression of somatostatin receptors], disease localization and extent, and resectability of primary and metastatic disease, are all key issues that shall be taken into consideration to appropriately tailor therapeutic strategies and surveillance of these patients. |
format | Online Article Text |
id | pubmed-4239790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-42397902014-11-25 SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014 Garcia-Carbonero, R. JImenez-Fonseca, P. Teulé, A. Barriuso, J. Sevilla, I. Clin Transl Oncol Clinical Guides in Oncology GEP-NENs are a challenging family of tumors of growing incidence and varied clinical management and behavior. Diagnostic techniques have substantially improved over the past decades and significant advances have been achieved in the understanding of the molecular pathways governing tumor initiation and progression. This has already translated into relevant advances in the clinic. This guideline aims to provide practical recommendations for the diagnosis and treatment of GEP-NENs. Diagnostic workup, histological and staging classifications, and the different available therapeutic approaches, including surgery, liver-directed ablative therapies, peptide receptor radionuclide therapy, and systemic hormonal, cytotoxic or targeted therapy, are briefly discussed in this manuscript. Clinical presentation (performance status, comorbidities, tumor-derived symptoms and hormone syndrome in functioning tumors), histological features [tumor differentiation, proliferation rate (Ki-67), and expression of somatostatin receptors], disease localization and extent, and resectability of primary and metastatic disease, are all key issues that shall be taken into consideration to appropriately tailor therapeutic strategies and surveillance of these patients. Springer Milan 2014-09-03 2014 /pmc/articles/PMC4239790/ /pubmed/25183048 http://dx.doi.org/10.1007/s12094-014-1214-6 Text en © Federación de Sociedades Españolas de Oncología (FESEO) 2014 |
spellingShingle | Clinical Guides in Oncology Garcia-Carbonero, R. JImenez-Fonseca, P. Teulé, A. Barriuso, J. Sevilla, I. SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014 |
title | SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014 |
title_full | SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014 |
title_fullStr | SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014 |
title_full_unstemmed | SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014 |
title_short | SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) 2014 |
title_sort | seom clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms (gep-nens) 2014 |
topic | Clinical Guides in Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239790/ https://www.ncbi.nlm.nih.gov/pubmed/25183048 http://dx.doi.org/10.1007/s12094-014-1214-6 |
work_keys_str_mv | AT garciacarboneror seomclinicalguidelinesforthediagnosisandtreatmentofgastroenteropancreaticneuroendocrineneoplasmsgepnens2014 AT jimenezfonsecap seomclinicalguidelinesforthediagnosisandtreatmentofgastroenteropancreaticneuroendocrineneoplasmsgepnens2014 AT teulea seomclinicalguidelinesforthediagnosisandtreatmentofgastroenteropancreaticneuroendocrineneoplasmsgepnens2014 AT barriusoj seomclinicalguidelinesforthediagnosisandtreatmentofgastroenteropancreaticneuroendocrineneoplasmsgepnens2014 AT sevillai seomclinicalguidelinesforthediagnosisandtreatmentofgastroenteropancreaticneuroendocrineneoplasmsgepnens2014 |