Single-Molecule Study of Proteins by Biological Nanopore Sensors

Nanopore technology has been developed for detecting properties of proteins through monitoring of ionic current modulations as protein passes via a nanosize pore. As a real-time, sensitive, selective and stable technology, biological nanopores are of widespread concern. Here, we introduce the backgr...

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Detalles Bibliográficos
Autores principales: Wu, Dongmei, Bi, Sheng, Zhang, Liyu, Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239869/
https://www.ncbi.nlm.nih.gov/pubmed/25268917
http://dx.doi.org/10.3390/s141018211
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author Wu, Dongmei
Bi, Sheng
Zhang, Liyu
Yang, Jun
author_facet Wu, Dongmei
Bi, Sheng
Zhang, Liyu
Yang, Jun
author_sort Wu, Dongmei
collection PubMed
description Nanopore technology has been developed for detecting properties of proteins through monitoring of ionic current modulations as protein passes via a nanosize pore. As a real-time, sensitive, selective and stable technology, biological nanopores are of widespread concern. Here, we introduce the background of nanopore researches in the area of α-hemolysin (α-HL) nanopores in protein conformation detections and protein–ligand interactions. Moreover, several original biological nanopores are also introduced with various features and functions.
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spelling pubmed-42398692014-11-21 Single-Molecule Study of Proteins by Biological Nanopore Sensors Wu, Dongmei Bi, Sheng Zhang, Liyu Yang, Jun Sensors (Basel) Review Nanopore technology has been developed for detecting properties of proteins through monitoring of ionic current modulations as protein passes via a nanosize pore. As a real-time, sensitive, selective and stable technology, biological nanopores are of widespread concern. Here, we introduce the background of nanopore researches in the area of α-hemolysin (α-HL) nanopores in protein conformation detections and protein–ligand interactions. Moreover, several original biological nanopores are also introduced with various features and functions. MDPI 2014-09-29 /pmc/articles/PMC4239869/ /pubmed/25268917 http://dx.doi.org/10.3390/s141018211 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Dongmei
Bi, Sheng
Zhang, Liyu
Yang, Jun
Single-Molecule Study of Proteins by Biological Nanopore Sensors
title Single-Molecule Study of Proteins by Biological Nanopore Sensors
title_full Single-Molecule Study of Proteins by Biological Nanopore Sensors
title_fullStr Single-Molecule Study of Proteins by Biological Nanopore Sensors
title_full_unstemmed Single-Molecule Study of Proteins by Biological Nanopore Sensors
title_short Single-Molecule Study of Proteins by Biological Nanopore Sensors
title_sort single-molecule study of proteins by biological nanopore sensors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239869/
https://www.ncbi.nlm.nih.gov/pubmed/25268917
http://dx.doi.org/10.3390/s141018211
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