Cargando…

Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4(fky/fky) mouse

Mitochondrial dysfunction causes a range of early-onset neurological diseases and contributes to neurodegenerative conditions. The mechanisms of neurological damage however are poorly understood, as accessing relevant tissue from patients is difficult, and appropriate models are limited. Hence, we a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bird, Matthew J., Wijeyeratne, Xiaonan W., Komen, Jasper C., Laskowski, Adrienne, Ryan, Michael T., Thorburn, David R., Frazier, Ann E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240023/ https://www.ncbi.nlm.nih.gov/pubmed/25312000 http://dx.doi.org/10.1042/BSR20140151

Ejemplares similares

Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632
por: Koike, Rima, et al.
Publicado: (2022)

Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-7382
por: Matsuo, Hirotaka, et al.
Publicado: (2020)

Expansion of the clinical and neuroimaging spectrum associated with NDUFS8‐related disorder
por: Andzelm, Milena M., et al.
Publicado: (2022)

Double administration of self-complementary AAV9(NDUFS4) prevents Leigh disease in Ndufs4(−/−) mice
por: Corrà, Samantha, et al.
Publicado: (2022)

Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice
por: Wang, Mei, et al.
Publicado: (2017)

Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
por: Braidy, Nady, et al.
Publicado: (2013)

The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I
por: Su, Chia-Yi, et al.
Publicado: (2016)

A Single Intravenous Injection of AAV-PHP.B-hNDUFS4 Ameliorates the Phenotype of Ndufs4(−/−) Mice
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2020)

CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons
por: Aravantinou-Fatorou, Katerina, et al.
Publicado: (2015)

Cardiac-specific overexpression of Ndufs1 ameliorates cardiac dysfunction after myocardial infarction by alleviating mitochondrial dysfunction and apoptosis
por: Qi, Bingchao, et al.
Publicado: (2022)

Ndufs4 ablation decreases synaptophysin expression in hippocampus
por: Shil, Subrata Kumar, et al.
Publicado: (2021)

Mitochondrial Ultrastructural Defects in NDUFS3-Related Disorder
por: Samanta, Debopam, et al.
Publicado: (2021)

Ndufs1 Deficiency Aggravates the Mitochondrial Membrane Potential Dysfunction in Pressure Overload-Induced Myocardial Hypertrophy
por: Zou, Rongjun, et al.
Publicado: (2021)

NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease
por: Mise, Koki, et al.
Publicado: (2023)

Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons
por: Choi, Won-Seok, et al.
Publicado: (2017)

The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families
por: Tuppen, Helen A. L., et al.
Publicado: (2010)

Mutations in NDUFS1 Cause Metabolic Reprogramming and Disruption of the Electron Transfer
por: Ni, Yang, et al.
Publicado: (2019)

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention
por: van de Wal, Melissa A E, et al.
Publicado: (2021)

LEVERAGING THE NDUFS4-/- MOUSE AS A PLATFORM FOR TESTING LONGEVITY INTERVENTIONS
por: Bitto, Alessandro, et al.
Publicado: (2022)

Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults
por: Sterpka, Ashley, et al.
Publicado: (2020)

Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain
por: Kayser, Ernst-Bernhard, et al.
Publicado: (2016)

Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6
por: Zhang, Yuelin, et al.
Publicado: (2020)

Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases
por: Wang, Sifan, et al.
Publicado: (2022)

Peripheral macrophages drive CNS disease in the Ndufs4(−/−) model of Leigh syndrome
por: Hanaford, Allison R., et al.
Publicado: (2023)

NDUFB11 and NDUFS3 play a role in atherosclerosis and chronic stress
por: Yang, Yin, et al.
Publicado: (2023)

Lineage tracing of Foxd1‐expressing embryonic progenitors to assess the role of divergent embryonic lineages on adult dermal fibroblast function
por: Walker, John T., et al.
Publicado: (2021)

Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome
por: Chen, Byron, et al.
Publicado: (2017)

Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells
por: Suhane, Sonal, et al.
Publicado: (2013)

NDUFAF7 Methylates Arginine 85 in the NDUFS2 Subunit of Human Complex I
por: Rhein, Virginie F., et al.
Publicado: (2013)

NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I
por: Rhein, Virginie F., et al.
Publicado: (2016)

Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model
por: Foriel, Sarah, et al.
Publicado: (2018)

Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity
por: Ramadasan-Nair, Renjini, et al.
Publicado: (2017)

Leukocytes mediate disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome
por: Stokes, Julia C., et al.
Publicado: (2022)

Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
por: Aguilar, Kevin, et al.
Publicado: (2022)

Nonviral Direct Conversion of Primary Mouse Embryonic Fibroblasts to Neuronal Cells
por: Adler, Andrew F, et al.
Publicado: (2012)

One-carbon metabolite supplementation improves growth of bovine embryonic fibroblasts cultured in divergent glucose media
por: Crouse, Matthew S, et al.
Publicado: (2019)

DNA methylation dataset of bovine embryonic fibroblast cells treated with epigenetic modifiers and divergent energy supply
por: Diniz, Wellison J.S., et al.
Publicado: (2022)

Altered Anesthetic Sensitivity of Mice Lacking Ndufs4, a Subunit of Mitochondrial Complex I
por: Quintana, Albert, et al.
Publicado: (2012)

Novel NDUFS4 gene mutation in an atypical late-onset mitochondrial form of multifocal dystonia
por: Bris, Celine, et al.
Publicado: (2017)

Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
por: McElroy, Gregory S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fj0t7c1n60l4r3t57j8hu5lrrf