Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes

AIMS: During activation of cardiac myocytes, less than 1% of cytosolic Ca is free; the rest is bound to buffers, largely SERCA, and troponin C. Signalling by phosphorylation, as occurs during β-adrenergic stimulation, changes the Ca-binding affinity of these proteins and may affect the systolic Ca t...

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Detalles Bibliográficos
Autores principales: Briston, Sarah J., Dibb, Katharine M., Solaro, R. John, Eisner, David A., Trafford, Andrew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240166/
https://www.ncbi.nlm.nih.gov/pubmed/25183792
http://dx.doi.org/10.1093/cvr/cvu201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240166/
https://www.ncbi.nlm.nih.gov/pubmed/25183792
http://dx.doi.org/10.1093/cvr/cvu201

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