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Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes
AIMS: During activation of cardiac myocytes, less than 1% of cytosolic Ca is free; the rest is bound to buffers, largely SERCA, and troponin C. Signalling by phosphorylation, as occurs during β-adrenergic stimulation, changes the Ca-binding affinity of these proteins and may affect the systolic Ca t...
Autores principales: | Briston, Sarah J., Dibb, Katharine M., Solaro, R. John, Eisner, David A., Trafford, Andrew W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240166/ https://www.ncbi.nlm.nih.gov/pubmed/25183792 http://dx.doi.org/10.1093/cvr/cvu201 |
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