Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI)

Two cases of malignant hypertension presenting with acute kidney injury, thrombocytopenia and hemolytic anemia are presented. In both patients a prolonged duration of renal replacement therapy was required. The plasma levels of ADAMTS13 enzyme were not helpful in delineating the precise pathogenesis...

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Autores principales: Nzerue, Chike, Oluwole, Kemi, Adejorin, David, Paueksakon, Paisit, Fremont, Richard, Akatue, Richmond, Faulkner, Marquetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240409/
https://www.ncbi.nlm.nih.gov/pubmed/25503954
http://dx.doi.org/10.1093/ckj/sfu116
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author Nzerue, Chike
Oluwole, Kemi
Adejorin, David
Paueksakon, Paisit
Fremont, Richard
Akatue, Richmond
Faulkner, Marquetta
author_facet Nzerue, Chike
Oluwole, Kemi
Adejorin, David
Paueksakon, Paisit
Fremont, Richard
Akatue, Richmond
Faulkner, Marquetta
author_sort Nzerue, Chike
collection PubMed
description Two cases of malignant hypertension presenting with acute kidney injury, thrombocytopenia and hemolytic anemia are presented. In both patients a prolonged duration of renal replacement therapy was required. The plasma levels of ADAMTS13 enzyme were not helpful in delineating the precise pathogenesis in both cases, as the decrements were not severe. We discuss the clinic-pathologic correlation of the biopsy findings and persistence of AKI.
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spelling pubmed-42404092014-11-21 Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI) Nzerue, Chike Oluwole, Kemi Adejorin, David Paueksakon, Paisit Fremont, Richard Akatue, Richmond Faulkner, Marquetta Clin Kidney J Original Contributions Two cases of malignant hypertension presenting with acute kidney injury, thrombocytopenia and hemolytic anemia are presented. In both patients a prolonged duration of renal replacement therapy was required. The plasma levels of ADAMTS13 enzyme were not helpful in delineating the precise pathogenesis in both cases, as the decrements were not severe. We discuss the clinic-pathologic correlation of the biopsy findings and persistence of AKI. Oxford University Press 2014-12 2014-11-13 /pmc/articles/PMC4240409/ /pubmed/25503954 http://dx.doi.org/10.1093/ckj/sfu116 Text en © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Contributions
Nzerue, Chike
Oluwole, Kemi
Adejorin, David
Paueksakon, Paisit
Fremont, Richard
Akatue, Richmond
Faulkner, Marquetta
Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI)
title Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI)
title_full Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI)
title_fullStr Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI)
title_full_unstemmed Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI)
title_short Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI)
title_sort malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (aki)
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240409/
https://www.ncbi.nlm.nih.gov/pubmed/25503954
http://dx.doi.org/10.1093/ckj/sfu116
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