Cargando…

Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda

BACKGROUND: Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda. METHODS: 195 consenting HIV-positive, HAART naïve men aged 12...

Descripción completa

Detalles Bibliográficos
Autores principales: Kigozi, Godfrey, Musoke, Richard, Kighoma, Nehemiah, Watya, Stephen, Serwadda, David, Nalugoda, Fred, Kiwanuka, Noah, Wabwire-Mangen, Fred, Tobian, Aaron, Makumbi, Fredrick, Galiwango, Ronald Moses, Sewankambo, Nelson, Nkale, James, Nalwoga, Grace Kigozi, Anyokorit, Margaret, Lutalo, Tom, Gray, Ronald Henry, Wawer, Maria Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240554/
https://www.ncbi.nlm.nih.gov/pubmed/25415874
http://dx.doi.org/10.1371/journal.pone.0110382
_version_ 1782345730485125120
author Kigozi, Godfrey
Musoke, Richard
Kighoma, Nehemiah
Watya, Stephen
Serwadda, David
Nalugoda, Fred
Kiwanuka, Noah
Wabwire-Mangen, Fred
Tobian, Aaron
Makumbi, Fredrick
Galiwango, Ronald Moses
Sewankambo, Nelson
Nkale, James
Nalwoga, Grace Kigozi
Anyokorit, Margaret
Lutalo, Tom
Gray, Ronald Henry
Wawer, Maria Joan
author_facet Kigozi, Godfrey
Musoke, Richard
Kighoma, Nehemiah
Watya, Stephen
Serwadda, David
Nalugoda, Fred
Kiwanuka, Noah
Wabwire-Mangen, Fred
Tobian, Aaron
Makumbi, Fredrick
Galiwango, Ronald Moses
Sewankambo, Nelson
Nkale, James
Nalwoga, Grace Kigozi
Anyokorit, Margaret
Lutalo, Tom
Gray, Ronald Henry
Wawer, Maria Joan
author_sort Kigozi, Godfrey
collection PubMed
description BACKGROUND: Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda. METHODS: 195 consenting HIV-positive, HAART naïve men aged 12 and above provided blood for plasma HIV viral load testing before surgery and weekly for six weeks and at 2 and 3 months post surgery. Data were also collected on baseline social demographic characteristics and CD4 counts. Change in log(10) plasma viral load between baseline and follow-up visits was estimated using paired t tests and multivariate generalized estimating equation (GEE). RESULTS: Of the 195 men, 129 had a CD4 count ≧350 and 66 had CD4 <350 cells/mm(3). Men with CD4 counts <350 had higher baseline mean log(10) plasma viral load than those with CD4 counts ≧350 cells/mm(3) (4.715 vs 4.217 cps/mL, respectively, p = 0.0005). Compared to baseline, there was no statistically significant increase in post-MC HIV plasma viral loads irrespective of CD4. Multivariate analysis showed that higher baseline log(10) plasma viral load was significantly associated with reduction in mean log(10) plasma viral load following MC (coef.  = −0.134, p<0.001). CONCLUSION: We observed no increase in plasma HIV viral load following MC in HIV-infected, HAART naïve men.
format Online
Article
Text
id pubmed-4240554
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-42405542014-11-26 Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda Kigozi, Godfrey Musoke, Richard Kighoma, Nehemiah Watya, Stephen Serwadda, David Nalugoda, Fred Kiwanuka, Noah Wabwire-Mangen, Fred Tobian, Aaron Makumbi, Fredrick Galiwango, Ronald Moses Sewankambo, Nelson Nkale, James Nalwoga, Grace Kigozi Anyokorit, Margaret Lutalo, Tom Gray, Ronald Henry Wawer, Maria Joan PLoS One Research Article BACKGROUND: Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda. METHODS: 195 consenting HIV-positive, HAART naïve men aged 12 and above provided blood for plasma HIV viral load testing before surgery and weekly for six weeks and at 2 and 3 months post surgery. Data were also collected on baseline social demographic characteristics and CD4 counts. Change in log(10) plasma viral load between baseline and follow-up visits was estimated using paired t tests and multivariate generalized estimating equation (GEE). RESULTS: Of the 195 men, 129 had a CD4 count ≧350 and 66 had CD4 <350 cells/mm(3). Men with CD4 counts <350 had higher baseline mean log(10) plasma viral load than those with CD4 counts ≧350 cells/mm(3) (4.715 vs 4.217 cps/mL, respectively, p = 0.0005). Compared to baseline, there was no statistically significant increase in post-MC HIV plasma viral loads irrespective of CD4. Multivariate analysis showed that higher baseline log(10) plasma viral load was significantly associated with reduction in mean log(10) plasma viral load following MC (coef.  = −0.134, p<0.001). CONCLUSION: We observed no increase in plasma HIV viral load following MC in HIV-infected, HAART naïve men. Public Library of Science 2014-11-21 /pmc/articles/PMC4240554/ /pubmed/25415874 http://dx.doi.org/10.1371/journal.pone.0110382 Text en © 2014 Kigozi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kigozi, Godfrey
Musoke, Richard
Kighoma, Nehemiah
Watya, Stephen
Serwadda, David
Nalugoda, Fred
Kiwanuka, Noah
Wabwire-Mangen, Fred
Tobian, Aaron
Makumbi, Fredrick
Galiwango, Ronald Moses
Sewankambo, Nelson
Nkale, James
Nalwoga, Grace Kigozi
Anyokorit, Margaret
Lutalo, Tom
Gray, Ronald Henry
Wawer, Maria Joan
Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda
title Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda
title_full Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda
title_fullStr Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda
title_full_unstemmed Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda
title_short Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda
title_sort effects of medical male circumcision (mc) on plasma hiv viral load in hiv+ haart naïve men; rakai, uganda
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240554/
https://www.ncbi.nlm.nih.gov/pubmed/25415874
http://dx.doi.org/10.1371/journal.pone.0110382
work_keys_str_mv AT kigozigodfrey effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT musokerichard effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT kighomanehemiah effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT watyastephen effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT serwaddadavid effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT nalugodafred effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT kiwanukanoah effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT wabwiremangenfred effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT tobianaaron effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT makumbifredrick effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT galiwangoronaldmoses effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT sewankambonelson effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT nkalejames effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT nalwogagracekigozi effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT anyokoritmargaret effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT lutalotom effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT grayronaldhenry effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda
AT wawermariajoan effectsofmedicalmalecircumcisionmconplasmahivviralloadinhivhaartnaivemenrakaiuganda