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Downregulation of hTERT: An Important As(2)O(3) Induced Mechanism of Apoptosis in Myelodysplastic Syndrome
Two myelodysplastic syndrome (MDS) celllines, MUTZ-1 and SKM-1 cells, were used to study the effect of arsenic trioxide (As(2)O(3)) on hematological malignant cells. As(2)O(3) induced this two cell lines apoptosis via activation of caspase-3/8 and cleavage of poly (ADP-ribose) polymerase (PARP), a D...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240556/ https://www.ncbi.nlm.nih.gov/pubmed/25415199 http://dx.doi.org/10.1371/journal.pone.0113199 |