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Akt Inhibition Promotes ABCA1-Mediated Cholesterol Efflux to ApoA-I through Suppressing mTORC1

ATP-binding cassette transporter A1 (ABCA1) plays an essential role in mediating cholesterol efflux to apolipoprotein A-I (apoA-I), a major housekeeping mechanism for cellular cholesterol homeostasis. After initial engagement with ABCA1, apoA-I directly interacts with the plasma membrane to acquire...

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Detalles Bibliográficos
Autores principales:	Dong, Fumin, Mo, Zhongcheng, Eid, Walaa, Courtney, Kevin C., Zha, Xiaohui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240609/ https://www.ncbi.nlm.nih.gov/pubmed/25415591 http://dx.doi.org/10.1371/journal.pone.0113789

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