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Bioactive compounds from Holothuria atra of Indian ocean
The sea cucumber (Holothuria atra) extracts have been evaluated for the presence of bioactive compounds and various biological activities. The methanol extracts showed anti proliferative activities against the Hela and MCF-7 cell lines. Similarly the inhibitory effects of Herpes simplex virus 1 and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240768/ https://www.ncbi.nlm.nih.gov/pubmed/25485207 http://dx.doi.org/10.1186/2193-1801-3-673 |
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author | Dhinakaran, Devaraj Isaac Lipton, Aaron Premnath |
author_facet | Dhinakaran, Devaraj Isaac Lipton, Aaron Premnath |
author_sort | Dhinakaran, Devaraj Isaac |
collection | PubMed |
description | The sea cucumber (Holothuria atra) extracts have been evaluated for the presence of bioactive compounds and various biological activities. The methanol extracts showed anti proliferative activities against the Hela and MCF-7 cell lines. Similarly the inhibitory effects of Herpes simplex virus 1 and 2 cells were detected using the plaque reduction assay. The extracts of H. atra were purified using the silica gel column chromatography. The active fractions collected were observed for antimicrobial activity. The GC-MS analysis showed the availability of 59 compounds. The active bioactive compounds found in the H. atra were analyzed and their structure was identified using the (1)HNMR and (13)C NMR experiments. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-3-673) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4240768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-42407682014-12-05 Bioactive compounds from Holothuria atra of Indian ocean Dhinakaran, Devaraj Isaac Lipton, Aaron Premnath Springerplus Research The sea cucumber (Holothuria atra) extracts have been evaluated for the presence of bioactive compounds and various biological activities. The methanol extracts showed anti proliferative activities against the Hela and MCF-7 cell lines. Similarly the inhibitory effects of Herpes simplex virus 1 and 2 cells were detected using the plaque reduction assay. The extracts of H. atra were purified using the silica gel column chromatography. The active fractions collected were observed for antimicrobial activity. The GC-MS analysis showed the availability of 59 compounds. The active bioactive compounds found in the H. atra were analyzed and their structure was identified using the (1)HNMR and (13)C NMR experiments. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-3-673) contains supplementary material, which is available to authorized users. Springer International Publishing 2014-11-14 /pmc/articles/PMC4240768/ /pubmed/25485207 http://dx.doi.org/10.1186/2193-1801-3-673 Text en © Dhinakaran and Lipton; licensee Springer. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Dhinakaran, Devaraj Isaac Lipton, Aaron Premnath Bioactive compounds from Holothuria atra of Indian ocean |
title | Bioactive compounds from Holothuria atra of Indian ocean |
title_full | Bioactive compounds from Holothuria atra of Indian ocean |
title_fullStr | Bioactive compounds from Holothuria atra of Indian ocean |
title_full_unstemmed | Bioactive compounds from Holothuria atra of Indian ocean |
title_short | Bioactive compounds from Holothuria atra of Indian ocean |
title_sort | bioactive compounds from holothuria atra of indian ocean |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240768/ https://www.ncbi.nlm.nih.gov/pubmed/25485207 http://dx.doi.org/10.1186/2193-1801-3-673 |
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