Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens, and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administ...

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Autores principales: Smith, Alexander C. W., Kupchik, Yonatan M., Scofield, Michael D., Gipson, Cassandra D., Wiggins, Armina, Kalivas, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241163/
https://www.ncbi.nlm.nih.gov/pubmed/25326689
http://dx.doi.org/10.1038/nn.3846
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author Smith, Alexander C. W.
Kupchik, Yonatan M.
Scofield, Michael D.
Gipson, Cassandra D.
Wiggins, Armina
Kalivas, Peter W.
author_facet Smith, Alexander C. W.
Kupchik, Yonatan M.
Scofield, Michael D.
Gipson, Cassandra D.
Wiggins, Armina
Kalivas, Peter W.
author_sort Smith, Alexander C. W.
collection PubMed
description Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens, and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.
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spelling pubmed-42411632015-06-01 Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases Smith, Alexander C. W. Kupchik, Yonatan M. Scofield, Michael D. Gipson, Cassandra D. Wiggins, Armina Kalivas, Peter W. Nat Neurosci Article Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens, and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity. 2014-10-19 2014-12 /pmc/articles/PMC4241163/ /pubmed/25326689 http://dx.doi.org/10.1038/nn.3846 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Smith, Alexander C. W.
Kupchik, Yonatan M.
Scofield, Michael D.
Gipson, Cassandra D.
Wiggins, Armina
Kalivas, Peter W.
Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
title Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
title_full Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
title_fullStr Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
title_full_unstemmed Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
title_short Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
title_sort synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241163/
https://www.ncbi.nlm.nih.gov/pubmed/25326689
http://dx.doi.org/10.1038/nn.3846
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