Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens, and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administ...

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Detalles Bibliográficos
Autores principales: Smith, Alexander C. W., Kupchik, Yonatan M., Scofield, Michael D., Gipson, Cassandra D., Wiggins, Armina, Kalivas, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241163/
https://www.ncbi.nlm.nih.gov/pubmed/25326689
http://dx.doi.org/10.1038/nn.3846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241163/
https://www.ncbi.nlm.nih.gov/pubmed/25326689
http://dx.doi.org/10.1038/nn.3846

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