Cargando…

Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel

BACKGROUND: Improvements in both performance and cost for next-generation sequencing (NGS) have spurred its rapid adoption for clinical applications. We designed and optimized a pan-cancer target-enrichment panel for 51 well-established oncogenes and tumor suppressors, in conjunction with a bioinfor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choudhary, Ashish, Mambo, Elizabeth, Sanford, Tiffany, Boedigheimer, Michael, Twomey, Brian, Califano, Joseph, Hadd, Andrew, Oliner, Kelly S, Beaudenon, Sylvie, Latham, Gary J, Adai, Alex T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241214/ https://www.ncbi.nlm.nih.gov/pubmed/25395014 http://dx.doi.org/10.1186/s12920-014-0062-0

Ejemplares similares

Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma
por: Gaykalova, Daria A., et al.
Publicado: (2014)

Correction: Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma
por: Gaykalova, Daria A., et al.
Publicado: (2020)

Serum microRNA Biomarkers for Detection of Non-Small Cell Lung Cancer
por: Hennessey, Patrick T., et al.
Publicado: (2012)

Correction: Serum microRNA Biomarkers for Detection of Non-Small Cell Lung Cancer
por: Hennessey, Patrick T., et al.
Publicado: (2012)

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
por: Houghton, Jeffrey, et al.
Publicado: (2016)

Identifying the determinants of response to MDM2 inhibition
por: Saiki, Anne Y., et al.
Publicado: (2015)

Impact of tumour RAS/BRAF status in a first-line study of panitumumab + FOLFIRI in patients with metastatic colorectal cancer
por: Karthaus, Meinolf, et al.
Publicado: (2016)

PA01.51.Enriching the core
por: Thakkar, Jayesh
Publicado: (2012)

A novel mean-centering method for normalizing microRNA expression from high-throughput RT-qPCR data
por: Wylie, Dennis, et al.
Publicado: (2011)

HPV E6, E6AP and cervical cancer
por: Beaudenon, Sylvie, et al.
Publicado: (2008)

The role of AGG interruptions in fragile X repeat expansions: a twenty-year perspective
por: Latham, Gary J., et al.
Publicado: (2014)

WEADE: A workflow for enrichment analysis and data exploration
por: Trost, Nils, et al.
Publicado: (2018)

Optimization of workflow and screening panels for the detection of malignant monoclonal gammopathies
por: Oliveros Conejero, Raquel, et al.
Publicado: (2020)

Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow
por: Giannopoulou, Efstathia, et al.
Publicado: (2019)

Comprehensive Mutation Analysis for Congenital Muscular Dystrophy: A Clinical PCR-Based Enrichment and Next-Generation Sequencing Panel
por: Valencia, C. Alexander, et al.
Publicado: (2013)

A direct comparison of next generation sequencing enrichment methods using an aortopathy gene panel- clinical diagnostics perspective
por: Wooderchak-Donahue, Whitney L, et al.
Publicado: (2012)

DNA Qualification Workflow for Next Generation Sequencing of Histopathological Samples
por: Simbolo, Michele, et al.
Publicado: (2013)

SMITH: a LIMS for handling next-generation sequencing workflows
por: Venco, Francesco, et al.
Publicado: (2014)

Letter concerning the next meeting of the Physics III Committee-72-51
por: Herz, A J
Publicado: (1972)

Challenges in the Setup of Large-scale Next-Generation Sequencing Analysis Workflows
por: Kulkarni, Pranav, et al.
Publicado: (2017)

51st International School of Subnuclear Physics on "Reflections on the next step for LHC"
por: Zichichi, Antonino
Publicado: (2015)

Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy
por: van Deutekom, Judith, et al.
Publicado: (2023)

Workflow optimization of whole genome amplification and targeted panel sequencing for CTC mutation detection
por: Liu, Haiyan E., et al.
Publicado: (2017)

EPIGEN-Brazil Initiative resources: a Latin American imputation panel and the Scientific Workflow
por: Magalhães, Wagner C.S., et al.
Publicado: (2018)

Improvement of workflow and processes to ease and enrich meaningful use of health information technology
por: Singh, Ranjit, et al.
Publicado: (2013)

Detecting copy number variation in next generation sequencing data from diagnostic gene panels
por: Singh, Ashish Kumar, et al.
Publicado: (2021)

Next Generation Sequence Analysis and Computational Genomics Using Graphical Pipeline Workflows
por: Torri, Federica, et al.
Publicado: (2012)

Feasibility of a workflow for the molecular characterization of single cells by next generation sequencing
por: Salvianti, Francesca, et al.
Publicado: (2015)

Age of ovarian cancer diagnosis among BRIP1, RAD51C, and RAD51D mutation carriers identified through multi-gene panel testing
por: Cummings, Shelly, et al.
Publicado: (2021)

Internet Explorer 8 and its impact on your ASP.NET web sites
por: Boedigheimer, Robert
Publicado: (2009)

An extension of the BioAssay Ontology to include pharmacokinetic/pharmacodynamic terminology for the enrichment of scientific workflows
por: Penn, Steve, et al.
Publicado: (2023)

Acoustic surface waves
por: Oliner, A A
Publicado: (1978)

A methylation PCR method determines FMR1 activation ratios and differentiates premutation allele mosaicism in carrier siblings
por: Hadd, Andrew G., et al.
Publicado: (2016)

Molecular classification of thyroid lesions by combined testing for miRNA gene expression and somatic gene alterations
por: Wylie, Dennis, et al.
Publicado: (2016)

An enriched sugarcane diversity panel for utilization in genetic improvement of sugarcane
por: Fickett, Nathanael D., et al.
Publicado: (2020)

Full Digital Workflow for Mandibular Ameloblastoma Management: Showcase for Technical Description
por: Abbate, Vincenzo, et al.
Publicado: (2023)

Targeted next generation sequencing with an extended gene panel does not impact variant detection in mitochondrial diseases
por: Plutino, Morgane, et al.
Publicado: (2018)

Succinct workflows for circulating tumor cells after enrichment: From systematic counting to mutational profiling
por: Wong, Victor Chun-Lam, et al.
Publicado: (2017)

An experimental workflow for enrichment of low abundant proteins from human serum for the discovery of serum biomarkers
por: Sarihan, Mehmet, et al.
Publicado: (2023)

The Beavis Effect in Next-Generation Mapping Panels in Drosophila melanogaster
por: King, Elizabeth G., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hdia8srf956t8ri181q8mgenal