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A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs
This study was conducted in order to characterize the pharmacokinetics of orally administered cephalexin to healthy adult and aged dogs, using a population pharmacokinetic approach. Two hundred and eighty-six cephalexin plasma concentrations obtained from previous pharmacokinetic studies were used....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241252/ https://www.ncbi.nlm.nih.gov/pubmed/25431741 http://dx.doi.org/10.1155/2014/789353 |
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author | Prados, Ana Paula Schaiquevich, Paula Kreil, Verónica Monfrinotti, Agustina Quaine, Pamela Tarragona, Lisa Hallu, Ruben Rebuelto, Marcela |
author_facet | Prados, Ana Paula Schaiquevich, Paula Kreil, Verónica Monfrinotti, Agustina Quaine, Pamela Tarragona, Lisa Hallu, Ruben Rebuelto, Marcela |
author_sort | Prados, Ana Paula |
collection | PubMed |
description | This study was conducted in order to characterize the pharmacokinetics of orally administered cephalexin to healthy adult and aged dogs, using a population pharmacokinetic approach. Two hundred and eighty-six cephalexin plasma concentrations obtained from previous pharmacokinetic studies were used. Sex, age, pharmaceutical formulation, and breed were evaluated as covariates. A one-compartment model with an absorption lag-time (Tlag) best described the data. The final model included age (adult; aged) on apparent volume of distribution (Vd/F), apparent elimination rate (ke/F), and Tlag; sex (female; male) on ke/F, and breed (Beagle; mixed-breed) on Vd/F. Addition of the covariates to the model explained 78% of the interindividal variability (IIV) in Vd/F, 36% in ke/F, and 24% in Tlag, respectively. Formulation did not affect the variability of any of the pharmacokinetic parameters. Tlag was longer, whereas Vd/F and ke/F were lower in aged compared to adult animals; in female aged dogs ke/F was lower than in male aged dogs; however, the differences were of low magnitude. Different disposition of cephalexin may be expected in aged dogs. |
format | Online Article Text |
id | pubmed-4241252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42412522014-11-27 A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs Prados, Ana Paula Schaiquevich, Paula Kreil, Verónica Monfrinotti, Agustina Quaine, Pamela Tarragona, Lisa Hallu, Ruben Rebuelto, Marcela Vet Med Int Research Article This study was conducted in order to characterize the pharmacokinetics of orally administered cephalexin to healthy adult and aged dogs, using a population pharmacokinetic approach. Two hundred and eighty-six cephalexin plasma concentrations obtained from previous pharmacokinetic studies were used. Sex, age, pharmaceutical formulation, and breed were evaluated as covariates. A one-compartment model with an absorption lag-time (Tlag) best described the data. The final model included age (adult; aged) on apparent volume of distribution (Vd/F), apparent elimination rate (ke/F), and Tlag; sex (female; male) on ke/F, and breed (Beagle; mixed-breed) on Vd/F. Addition of the covariates to the model explained 78% of the interindividal variability (IIV) in Vd/F, 36% in ke/F, and 24% in Tlag, respectively. Formulation did not affect the variability of any of the pharmacokinetic parameters. Tlag was longer, whereas Vd/F and ke/F were lower in aged compared to adult animals; in female aged dogs ke/F was lower than in male aged dogs; however, the differences were of low magnitude. Different disposition of cephalexin may be expected in aged dogs. Hindawi Publishing Corporation 2014 2014-11-06 /pmc/articles/PMC4241252/ /pubmed/25431741 http://dx.doi.org/10.1155/2014/789353 Text en Copyright © 2014 Ana Paula Prados et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Prados, Ana Paula Schaiquevich, Paula Kreil, Verónica Monfrinotti, Agustina Quaine, Pamela Tarragona, Lisa Hallu, Ruben Rebuelto, Marcela A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs |
title | A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs |
title_full | A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs |
title_fullStr | A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs |
title_full_unstemmed | A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs |
title_short | A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs |
title_sort | population pharmacokinetic approach to describe cephalexin disposition in adult and aged dogs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241252/ https://www.ncbi.nlm.nih.gov/pubmed/25431741 http://dx.doi.org/10.1155/2014/789353 |
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