Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice

Tak1 is a MAPKKK that can be activated by growth factors and cytokines such as RANKL and BMPs and its downstream pathways include NF-κB and JNK/p38 MAPKs. Tak1 is essential for mouse embryonic development and plays critical roles in tissue homeostasis. Previous studies have shown that Tak1 is a posi...

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Detalles Bibliográficos
Autores principales: Qi, Bing, Cong, Qian, Li, Ping, Ma, Gang, Guo, Xizhi, Yeh, James, Xie, Min, Schneider, Michael D., Liu, Huijuan, Li, Baojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241509/
https://www.ncbi.nlm.nih.gov/pubmed/25418008
http://dx.doi.org/10.1038/srep07158

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