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Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia
OBJECTIVE: Mesenteric arteries release C-type natriuretic peptide (CNP), which hyperpolarises vascular smooth muscle. We measured the levels of this peptide after inducing mesenteric ischaemia over a series of time intervals, so as to determine its predictive value in demonstrating the severity of i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Clinics Cardive Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241590/ https://www.ncbi.nlm.nih.gov/pubmed/24967686 http://dx.doi.org/10.5830/CVJA-2014-033 |
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author | Demirtas, Sinan Karahan, Oguz Yazici, Suleyman Guclu, Orkut Caliskan, Ahmet Tezcan, Orhan Yavuz, Celal |
author_facet | Demirtas, Sinan Karahan, Oguz Yazici, Suleyman Guclu, Orkut Caliskan, Ahmet Tezcan, Orhan Yavuz, Celal |
author_sort | Demirtas, Sinan |
collection | PubMed |
description | OBJECTIVE: Mesenteric arteries release C-type natriuretic peptide (CNP), which hyperpolarises vascular smooth muscle. We measured the levels of this peptide after inducing mesenteric ischaemia over a series of time intervals, so as to determine its predictive value in demonstrating the severity of ischaemia in a rat model. METHODS: A total of 32 rats were allocated to four groups containing eight rats each. Basal CNP reference levels were measured in the control group, which was not exposed to any intervention. In groups I, II and III, mesenteric ischaemia was induced over three, six and nine hours, respectively, and plasma CNP levels were measured afterwards. Mesenteric ischaemia was induced by clamping the superior mesenteric artery. RESULTS: In comparison with the controls (2.38 ± 0.18 pg/ml), CNP levels were relatively lower in group I (2.54 ± 0.42 pg/ml). However, significant increases in plasma CNP levels were observed over longer periods of ischaemia in group II, at 5.23 ± 0.22 pg/ml, and in group III, at 6.19 ± 0.67 pg/ml (p < 0.05). A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia (R = 0.56, p < 0.001). CONCLUSION: Measuring plasma CNP levels in patients with acute mesenteric ischaemia may be beneficial in estimating the time period over which the ischaemic injury has occurred. |
format | Online Article Text |
id | pubmed-4241590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Clinics Cardive Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-42415902015-04-10 Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia Demirtas, Sinan Karahan, Oguz Yazici, Suleyman Guclu, Orkut Caliskan, Ahmet Tezcan, Orhan Yavuz, Celal Cardiovasc J Afr Cardiovascular Topics OBJECTIVE: Mesenteric arteries release C-type natriuretic peptide (CNP), which hyperpolarises vascular smooth muscle. We measured the levels of this peptide after inducing mesenteric ischaemia over a series of time intervals, so as to determine its predictive value in demonstrating the severity of ischaemia in a rat model. METHODS: A total of 32 rats were allocated to four groups containing eight rats each. Basal CNP reference levels were measured in the control group, which was not exposed to any intervention. In groups I, II and III, mesenteric ischaemia was induced over three, six and nine hours, respectively, and plasma CNP levels were measured afterwards. Mesenteric ischaemia was induced by clamping the superior mesenteric artery. RESULTS: In comparison with the controls (2.38 ± 0.18 pg/ml), CNP levels were relatively lower in group I (2.54 ± 0.42 pg/ml). However, significant increases in plasma CNP levels were observed over longer periods of ischaemia in group II, at 5.23 ± 0.22 pg/ml, and in group III, at 6.19 ± 0.67 pg/ml (p < 0.05). A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia (R = 0.56, p < 0.001). CONCLUSION: Measuring plasma CNP levels in patients with acute mesenteric ischaemia may be beneficial in estimating the time period over which the ischaemic injury has occurred. Clinics Cardive Publishing 2014 /pmc/articles/PMC4241590/ /pubmed/24967686 http://dx.doi.org/10.5830/CVJA-2014-033 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cardiovascular Topics Demirtas, Sinan Karahan, Oguz Yazici, Suleyman Guclu, Orkut Caliskan, Ahmet Tezcan, Orhan Yavuz, Celal Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia |
title | Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia |
title_full | Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia |
title_fullStr | Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia |
title_full_unstemmed | Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia |
title_short | Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia |
title_sort | diagnostic value of plasma c-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia |
topic | Cardiovascular Topics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241590/ https://www.ncbi.nlm.nih.gov/pubmed/24967686 http://dx.doi.org/10.5830/CVJA-2014-033 |
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