Cargando…
Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment
The phenomenon that adverse environmental exposures in early life are associated with increased susceptibilities for many adult, particularly metabolic diseases, is now referred to as ‘developmental origins of health and disease (DOHAD)’ or ‘Barker’ hypothesis. Fetal overnutrition and undernutrition...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241689/ https://www.ncbi.nlm.nih.gov/pubmed/25187623 http://dx.doi.org/10.1530/REP-14-0334 |
_version_ | 1782345883135770624 |
---|---|
author | El Hajj, Nady Schneider, Eberhard Lehnen, Harald Haaf, Thomas |
author_facet | El Hajj, Nady Schneider, Eberhard Lehnen, Harald Haaf, Thomas |
author_sort | El Hajj, Nady |
collection | PubMed |
description | The phenomenon that adverse environmental exposures in early life are associated with increased susceptibilities for many adult, particularly metabolic diseases, is now referred to as ‘developmental origins of health and disease (DOHAD)’ or ‘Barker’ hypothesis. Fetal overnutrition and undernutrition have similar long-lasting effects on the setting of the neuroendocrine control systems, energy homeostasis, and metabolism, leading to life-long increased morbidity. There are sensitive time windows during early development, where environmental cues can program persistent epigenetic modifications which are generally assumed to mediate these gene–environment interactions. Most of our current knowledge on fetal programing comes from animal models and epidemiological studies in humans, in particular the Dutch famine birth cohort. In industrialized countries, there is more concern about adverse long-term consequences of fetal overnutrition, i.e. by exposure to gestational diabetes mellitus and/or maternal obesity which affect 10–20% of pregnancies. Epigenetic changes due to maternal diabetes/obesity may predispose the offspring to develop metabolic disease later in life and, thus, transmit the adverse environmental exposure to the next generation. This vicious cycle could contribute significantly to the worldwide metabolic disease epidemics. In this review article, we focus on the epigenetics of an adverse intrauterine environment, in particular gestational diabetes, and its implications for the prevention of complex disease. |
format | Online Article Text |
id | pubmed-4241689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42416892014-12-22 Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment El Hajj, Nady Schneider, Eberhard Lehnen, Harald Haaf, Thomas Reproduction Review The phenomenon that adverse environmental exposures in early life are associated with increased susceptibilities for many adult, particularly metabolic diseases, is now referred to as ‘developmental origins of health and disease (DOHAD)’ or ‘Barker’ hypothesis. Fetal overnutrition and undernutrition have similar long-lasting effects on the setting of the neuroendocrine control systems, energy homeostasis, and metabolism, leading to life-long increased morbidity. There are sensitive time windows during early development, where environmental cues can program persistent epigenetic modifications which are generally assumed to mediate these gene–environment interactions. Most of our current knowledge on fetal programing comes from animal models and epidemiological studies in humans, in particular the Dutch famine birth cohort. In industrialized countries, there is more concern about adverse long-term consequences of fetal overnutrition, i.e. by exposure to gestational diabetes mellitus and/or maternal obesity which affect 10–20% of pregnancies. Epigenetic changes due to maternal diabetes/obesity may predispose the offspring to develop metabolic disease later in life and, thus, transmit the adverse environmental exposure to the next generation. This vicious cycle could contribute significantly to the worldwide metabolic disease epidemics. In this review article, we focus on the epigenetics of an adverse intrauterine environment, in particular gestational diabetes, and its implications for the prevention of complex disease. Bioscientifica Ltd 2014-12 /pmc/articles/PMC4241689/ /pubmed/25187623 http://dx.doi.org/10.1530/REP-14-0334 Text en © 2014 The authors http://creativecommons.org/licenses/by/3.0/deed.en_GB This work is licensed under a Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/deed.en_GB) |
spellingShingle | Review El Hajj, Nady Schneider, Eberhard Lehnen, Harald Haaf, Thomas Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment |
title | Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment |
title_full | Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment |
title_fullStr | Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment |
title_full_unstemmed | Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment |
title_short | Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment |
title_sort | epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241689/ https://www.ncbi.nlm.nih.gov/pubmed/25187623 http://dx.doi.org/10.1530/REP-14-0334 |
work_keys_str_mv | AT elhajjnady epigeneticsandlifelongconsequencesofanadversenutritionalanddiabeticintrauterineenvironment AT schneidereberhard epigeneticsandlifelongconsequencesofanadversenutritionalanddiabeticintrauterineenvironment AT lehnenharald epigeneticsandlifelongconsequencesofanadversenutritionalanddiabeticintrauterineenvironment AT haafthomas epigeneticsandlifelongconsequencesofanadversenutritionalanddiabeticintrauterineenvironment |