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The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats

[PURPOSE]: Several epidemiological studies have demonstrated that there are positive correlations between vascular disorders and bone loss in postmenopausal women. The aim of the present study was to examine the effect of different types of exercise (e.g., climbing and swimming) for preventing endot...

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Autores principales: Park, Jonghoon, Omi, Naomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Exercise Nutrition 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241919/
https://www.ncbi.nlm.nih.gov/pubmed/25566448
http://dx.doi.org/10.5717/jenb.2014.18.2.133
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author Park, Jonghoon
Omi, Naomi
author_facet Park, Jonghoon
Omi, Naomi
author_sort Park, Jonghoon
collection PubMed
description [PURPOSE]: Several epidemiological studies have demonstrated that there are positive correlations between vascular disorders and bone loss in postmenopausal women. The aim of the present study was to examine the effect of different types of exercise (e.g., climbing and swimming) for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats. [METHODS]: Twenty Sprague-Dawley female rats were randomly divided into three groups: ovariectomy (OVX) plus treatment with vitamin D(3) and nicotine (VDN) (control rats [Con], n = 7), which is an animal model for endothelial dysfunction and bone loss; voluntary climbing resistance exercise with OVX plus VDN (climbing rats [Clim], n = 6), and swimming exercise with OVX plus VDN (swimming rats [Swim], n = 7). The period of exercise training was 8 weeks. [RESULTS]: The endothelin-1 (ET-1) protein levels were significantly lower in the Clim and Swim groups than in the Con. The endothelial nitric oxide synthase protein levels were significantly higher in the Swim group than in the Con, but they did not differ between the Clim and Con groups. The cortical bone mineral density in the tibia and breaking energy of the femur were significantly higher in the Clim group than in the Con, but this positive effect was not seen in the Swim group. [CONCLUSION]: Voluntary climbing exercise decreased arterial ET-1 protein levels and prevented bone loss in a postmenopause-model rat combining OVX and VDN. Conversely, swimming suppressed endothelial dysfunction of the arteries but did not prevent bone loss. Thus, the type of exercise should be cautiously chosen for enhancing vascular function and bone status, especially in females after menopause.
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spelling pubmed-42419192015-01-06 The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats Park, Jonghoon Omi, Naomi J Exerc Nutrition Biochem Original Paper [PURPOSE]: Several epidemiological studies have demonstrated that there are positive correlations between vascular disorders and bone loss in postmenopausal women. The aim of the present study was to examine the effect of different types of exercise (e.g., climbing and swimming) for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats. [METHODS]: Twenty Sprague-Dawley female rats were randomly divided into three groups: ovariectomy (OVX) plus treatment with vitamin D(3) and nicotine (VDN) (control rats [Con], n = 7), which is an animal model for endothelial dysfunction and bone loss; voluntary climbing resistance exercise with OVX plus VDN (climbing rats [Clim], n = 6), and swimming exercise with OVX plus VDN (swimming rats [Swim], n = 7). The period of exercise training was 8 weeks. [RESULTS]: The endothelin-1 (ET-1) protein levels were significantly lower in the Clim and Swim groups than in the Con. The endothelial nitric oxide synthase protein levels were significantly higher in the Swim group than in the Con, but they did not differ between the Clim and Con groups. The cortical bone mineral density in the tibia and breaking energy of the femur were significantly higher in the Clim group than in the Con, but this positive effect was not seen in the Swim group. [CONCLUSION]: Voluntary climbing exercise decreased arterial ET-1 protein levels and prevented bone loss in a postmenopause-model rat combining OVX and VDN. Conversely, swimming suppressed endothelial dysfunction of the arteries but did not prevent bone loss. Thus, the type of exercise should be cautiously chosen for enhancing vascular function and bone status, especially in females after menopause. Korean Society for Exercise Nutrition 2014-06 2014-05-15 /pmc/articles/PMC4241919/ /pubmed/25566448 http://dx.doi.org/10.5717/jenb.2014.18.2.133 Text en ⓒ2014 Korean Society for Exercise Nutrition This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Park, Jonghoon
Omi, Naomi
The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats
title The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats
title_full The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats
title_fullStr The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats
title_full_unstemmed The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats
title_short The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats
title_sort effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241919/
https://www.ncbi.nlm.nih.gov/pubmed/25566448
http://dx.doi.org/10.5717/jenb.2014.18.2.133
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