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Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens

BACKGROUND: Immunity that reduces worm fecundity and, in turn, reduces morbidity is proposed for Schistosoma haematobium, a parasite of major public health importance. Mathematical models of epidemiological trends suggest that antifecundity immunity is dependent on antibody responses to adult-worm-d...

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Autores principales: Wilson, Shona, Jones, Frances M., van Dam, Govert J., Corstjens, Paul L. A. M., Riveau, Gilles, Fitzsimmons, Colin M., Sacko, Moussa, Vennervald, Birgitte J., Dunne, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241947/
https://www.ncbi.nlm.nih.gov/pubmed/25001462
http://dx.doi.org/10.1093/infdis/jiu374
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author Wilson, Shona
Jones, Frances M.
van Dam, Govert J.
Corstjens, Paul L. A. M.
Riveau, Gilles
Fitzsimmons, Colin M.
Sacko, Moussa
Vennervald, Birgitte J.
Dunne, David W.
author_facet Wilson, Shona
Jones, Frances M.
van Dam, Govert J.
Corstjens, Paul L. A. M.
Riveau, Gilles
Fitzsimmons, Colin M.
Sacko, Moussa
Vennervald, Birgitte J.
Dunne, David W.
author_sort Wilson, Shona
collection PubMed
description BACKGROUND: Immunity that reduces worm fecundity and, in turn, reduces morbidity is proposed for Schistosoma haematobium, a parasite of major public health importance. Mathematical models of epidemiological trends suggest that antifecundity immunity is dependent on antibody responses to adult-worm-derived antigen. METHODS: For a Malian cohort (age, 5–29 years) residing in high-transmission fishing villages or a moderate-transmission village, worm fecundity was assessed using the ratio of urinary egg excretion to levels of circulating anodic antigen, a Schistosoma-specific antigen that is steadily secreted by adult worms. Fecundity was modeled against host age, infection transmission intensity, and antibody responses specific to soluble worm antigen (SWA), tegument allergen-like 1, and 28-kDa glutathione-S-transferase. RESULTS: Worm fecundity declined steadily until a host age of 11 years. Among children, host age and transmission were negatively associated with worm fecundity. A significant interaction term between host age and transmission indicates that antifecundity immunity develops earlier in high-transmission areas. SWA immunoglobulin G1 (IgG1) levels explained the effect of transmission on antifecundity immunity. CONCLUSION: Antifecundity immunity, which is likely to be protective against severe morbidity, develops rapidly during childhood. Antifecundity immunity is associated with SWA-IgG1, with higher infection transmission increasing this response at an earlier age, leading to earlier development of antifecundity immunity.
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spelling pubmed-42419472014-11-26 Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens Wilson, Shona Jones, Frances M. van Dam, Govert J. Corstjens, Paul L. A. M. Riveau, Gilles Fitzsimmons, Colin M. Sacko, Moussa Vennervald, Birgitte J. Dunne, David W. J Infect Dis Major Articles and Brief Reports BACKGROUND: Immunity that reduces worm fecundity and, in turn, reduces morbidity is proposed for Schistosoma haematobium, a parasite of major public health importance. Mathematical models of epidemiological trends suggest that antifecundity immunity is dependent on antibody responses to adult-worm-derived antigen. METHODS: For a Malian cohort (age, 5–29 years) residing in high-transmission fishing villages or a moderate-transmission village, worm fecundity was assessed using the ratio of urinary egg excretion to levels of circulating anodic antigen, a Schistosoma-specific antigen that is steadily secreted by adult worms. Fecundity was modeled against host age, infection transmission intensity, and antibody responses specific to soluble worm antigen (SWA), tegument allergen-like 1, and 28-kDa glutathione-S-transferase. RESULTS: Worm fecundity declined steadily until a host age of 11 years. Among children, host age and transmission were negatively associated with worm fecundity. A significant interaction term between host age and transmission indicates that antifecundity immunity develops earlier in high-transmission areas. SWA immunoglobulin G1 (IgG1) levels explained the effect of transmission on antifecundity immunity. CONCLUSION: Antifecundity immunity, which is likely to be protective against severe morbidity, develops rapidly during childhood. Antifecundity immunity is associated with SWA-IgG1, with higher infection transmission increasing this response at an earlier age, leading to earlier development of antifecundity immunity. Oxford University Press 2014-12-15 2014-07-07 /pmc/articles/PMC4241947/ /pubmed/25001462 http://dx.doi.org/10.1093/infdis/jiu374 Text en © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Wilson, Shona
Jones, Frances M.
van Dam, Govert J.
Corstjens, Paul L. A. M.
Riveau, Gilles
Fitzsimmons, Colin M.
Sacko, Moussa
Vennervald, Birgitte J.
Dunne, David W.
Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens
title Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens
title_full Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens
title_fullStr Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens
title_full_unstemmed Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens
title_short Human Schistosoma haematobium Antifecundity Immunity Is Dependent on Transmission Intensity and Associated With Immunoglobulin G1 to Worm-Derived Antigens
title_sort human schistosoma haematobium antifecundity immunity is dependent on transmission intensity and associated with immunoglobulin g1 to worm-derived antigens
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241947/
https://www.ncbi.nlm.nih.gov/pubmed/25001462
http://dx.doi.org/10.1093/infdis/jiu374
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