An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis

Amphotericin B (AmpB) is active against leishmaniasis, but its use is hampered due to its high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB (NQC-AmpB), containing chitosan and chondroitin sulfate molecules, was evaluated in BALB/c mice against Leishmania ama...

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Detalles Bibliográficos
Autores principales: Ribeiro, Tatiana G, Franca, Juçara R, Fuscaldi, Leonardo L, Santos, Mara L, Duarte, Mariana C, Lage, Paula S, Martins, Vivian T, Costa, Lourena E, Fernandes, Simone OA, Cardoso, Valbert N, Castilho, Rachel O, Soto, Manuel, Tavares, Carlos AP, Faraco, André AG, Coelho, Eduardo AF, Chávez-Fumagalli, Miguel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242406/
https://www.ncbi.nlm.nih.gov/pubmed/25429219
http://dx.doi.org/10.2147/IJN.S68966

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