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Sequence specificity incompletely defines the genome-wide occupancy of Myc

BACKGROUND: The Myc-Max heterodimer is a transcription factor that regulates expression of a large number of genes. Genome occupancy of Myc-Max is thought to be driven by Enhancer box (E-box) DNA elements, CACGTG or variants, to which the heterodimer binds in vitro. RESULTS: By analyzing ChIP-Seq da...

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Detalles Bibliográficos
Autores principales: Guo, Jiannan, Li, Tiandao, Schipper, Joshua, Nilson, Kyle A, Fordjour, Francis K, Cooper, Jeffrey J, Gordân, Raluca, Price, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242493/
https://www.ncbi.nlm.nih.gov/pubmed/25287278
http://dx.doi.org/10.1186/s13059-014-0482-3