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Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth

OBJECTIVES: Multiple myeloma (MM) is an incurable B-cell cancer with accumulated clonal abnormal plasma cells in bone marrow of patients. MCL-1 (myeloid cell leukemia sequence 1) protein is an anti-apoptotic molecule in MM cells and regulated by pro-inflammatory cytokine IL-6 and downstream signalin...

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Detalles Bibliográficos
Autores principales:	Wang, Mengchang, Wu, Di, Liu, Pengbo, Deng, Jiusheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242602/ https://www.ncbi.nlm.nih.gov/pubmed/25422792 http://dx.doi.org/10.1186/2162-3619-3-27

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