Elevated Expression of AKR1C3 Increases Resistance of Cancer Cells to Ionizing Radiation via Modulation of Oxidative Stress

With the aim to elucidate the etiology of radioresistance, we explored the genetic alterations in non-radioresistant vs. resistant esophageal cancer cells acquired by long-term fractionated radiation. We found AKR1C3, an aldo-keto reductase expressed seldom in most human tissues, expressed higher in...

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Detalles Bibliográficos
Autores principales: Xiong, Wei, Zhao, Jing, Yu, Hongliang, Li, Xiaoying, Sun, Shaoqian, Li, Yi, Xia, Qing, Zhang, Chuanling, He, Qiuchen, Gao, Xianshu, Zhang, Lihe, Zhou, Demin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242615/
https://www.ncbi.nlm.nih.gov/pubmed/25419901
http://dx.doi.org/10.1371/journal.pone.0111911

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