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Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging

PURPOSE: To assess the prognosis predictability of a measurable enhancing lesion using histogram parameters produced by the normalized cerebral blood volume (nCBV) and normalized apparent diffusion coefficient (nADC) after completion of standard concomitant chemoradiotherapy (CCRT) and adjuvant temo...

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Autores principales: Kim, Jae Hyun, Choi, Seung Hong, Ryoo, Inseon, Yun, Tae Jin, Kim, Tae Min, Lee, Se-Hoon, Park, Chul-Kee, Kim, Ji-Hoon, Sohn, Chul-Ho, Park, Sung-Hye, Kim, Il Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242641/
https://www.ncbi.nlm.nih.gov/pubmed/25419975
http://dx.doi.org/10.1371/journal.pone.0113587
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author Kim, Jae Hyun
Choi, Seung Hong
Ryoo, Inseon
Yun, Tae Jin
Kim, Tae Min
Lee, Se-Hoon
Park, Chul-Kee
Kim, Ji-Hoon
Sohn, Chul-Ho
Park, Sung-Hye
Kim, Il Han
author_facet Kim, Jae Hyun
Choi, Seung Hong
Ryoo, Inseon
Yun, Tae Jin
Kim, Tae Min
Lee, Se-Hoon
Park, Chul-Kee
Kim, Ji-Hoon
Sohn, Chul-Ho
Park, Sung-Hye
Kim, Il Han
author_sort Kim, Jae Hyun
collection PubMed
description PURPOSE: To assess the prognosis predictability of a measurable enhancing lesion using histogram parameters produced by the normalized cerebral blood volume (nCBV) and normalized apparent diffusion coefficient (nADC) after completion of standard concomitant chemoradiotherapy (CCRT) and adjuvant temozolomide (TMZ) medication in glioblastoma multiforme (GBM) patients. MATERIALS AND METHODS: This study was approved by the institutional review board (IRB), and the requirement for informed consent was waived. A total of 59 patients with newly diagnosed GBM who received standard CCRT with TMZ and adjuvant TMZ for six cycles underwent perfusion-weighted and diffusion-weighted imaging. Twenty-seven patients had a measurable enhancing lesion and 32 patients lacked a measurable enhancing lesion based on the Response Assessment in Neuro-Oncology (RANO) criteria in the follow-up MRI, which was performed within 3 months after adjuvant TMZ therapy was completed. We measured the nCBV and nADC histogram parameters based on the measurable enhancing lesion. The progression free survival (PFS) was analyzed by the Kaplan-Meier method with the use of the log-rank test. RESULTS: The median PFS of patients lacking measurable enhancing lesion was longer than for those with measurable enhancing lesions (17.6 vs 3.3 months, P<.0001). There was a significant, positive correlation between the 99(th) percentile nCBV value of a measurable enhancing lesion and the PFS (P = .044, R(2) = .152). In addition, the median PFS was longer in patients with a 99(th) percentile nCBV value ≧4.5 than it was in those with a value <4.5 (4.4 vs 3.1 months, P = .036). CONCLUSION: We found that the nCBV value can be used for the prognosis prediction of a measurable enhancing lesion after the completion of standard treatment for GBM, wherein a high 99(th) percentile nCBV value (≧4.5) suggests a better PFS for GBM patients.
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spelling pubmed-42426412014-11-26 Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging Kim, Jae Hyun Choi, Seung Hong Ryoo, Inseon Yun, Tae Jin Kim, Tae Min Lee, Se-Hoon Park, Chul-Kee Kim, Ji-Hoon Sohn, Chul-Ho Park, Sung-Hye Kim, Il Han PLoS One Research Article PURPOSE: To assess the prognosis predictability of a measurable enhancing lesion using histogram parameters produced by the normalized cerebral blood volume (nCBV) and normalized apparent diffusion coefficient (nADC) after completion of standard concomitant chemoradiotherapy (CCRT) and adjuvant temozolomide (TMZ) medication in glioblastoma multiforme (GBM) patients. MATERIALS AND METHODS: This study was approved by the institutional review board (IRB), and the requirement for informed consent was waived. A total of 59 patients with newly diagnosed GBM who received standard CCRT with TMZ and adjuvant TMZ for six cycles underwent perfusion-weighted and diffusion-weighted imaging. Twenty-seven patients had a measurable enhancing lesion and 32 patients lacked a measurable enhancing lesion based on the Response Assessment in Neuro-Oncology (RANO) criteria in the follow-up MRI, which was performed within 3 months after adjuvant TMZ therapy was completed. We measured the nCBV and nADC histogram parameters based on the measurable enhancing lesion. The progression free survival (PFS) was analyzed by the Kaplan-Meier method with the use of the log-rank test. RESULTS: The median PFS of patients lacking measurable enhancing lesion was longer than for those with measurable enhancing lesions (17.6 vs 3.3 months, P<.0001). There was a significant, positive correlation between the 99(th) percentile nCBV value of a measurable enhancing lesion and the PFS (P = .044, R(2) = .152). In addition, the median PFS was longer in patients with a 99(th) percentile nCBV value ≧4.5 than it was in those with a value <4.5 (4.4 vs 3.1 months, P = .036). CONCLUSION: We found that the nCBV value can be used for the prognosis prediction of a measurable enhancing lesion after the completion of standard treatment for GBM, wherein a high 99(th) percentile nCBV value (≧4.5) suggests a better PFS for GBM patients. Public Library of Science 2014-11-24 /pmc/articles/PMC4242641/ /pubmed/25419975 http://dx.doi.org/10.1371/journal.pone.0113587 Text en © 2014 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kim, Jae Hyun
Choi, Seung Hong
Ryoo, Inseon
Yun, Tae Jin
Kim, Tae Min
Lee, Se-Hoon
Park, Chul-Kee
Kim, Ji-Hoon
Sohn, Chul-Ho
Park, Sung-Hye
Kim, Il Han
Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging
title Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging
title_full Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging
title_fullStr Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging
title_full_unstemmed Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging
title_short Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging
title_sort prognosis prediction of measurable enhancing lesion after completion of standard concomitant chemoradiotherapy and adjuvant temozolomide in glioblastoma patients: application of dynamic susceptibility contrast perfusion and diffusion-weighted imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242641/
https://www.ncbi.nlm.nih.gov/pubmed/25419975
http://dx.doi.org/10.1371/journal.pone.0113587
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