Vaccinia Virus Induces Rapid Necrosis in Keratinocytes by a STAT3-Dependent Mechanism

RATIONALE: Humans with a dominant negative mutation in STAT3 are susceptible to severe skin infections, suggesting an essential role for STAT3 signaling in defense against cutaneous pathogens. METHODS: To focus on innate antiviral defenses in keratinocytes, we used a standard model of cutaneous infe...

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Detalles Bibliográficos
Autores principales: He, Yong, Fisher, Robert, Chowdhury, Soma, Sultana, Ishrat, Pereira, Claudia P., Bray, Mike, Reed, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242661/
https://www.ncbi.nlm.nih.gov/pubmed/25419841
http://dx.doi.org/10.1371/journal.pone.0113690

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