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Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2
Hypoxia-inducible factor 1α (HIF-1α), a major mediator of tumor physiology, is activated during tumor progression, and its abundance is correlated with therapeutic resistance in a broad range of solid tumors. The accumulation of HIF-1α is mainly caused by hypoxia or through the mutated succinate deh...
Autores principales: | Hou, Peifeng, Kuo, Ching-Ying, Cheng, Chun-Ting, Liou, Jing-Ping, Ann, David K., Chen, Qiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242664/ https://www.ncbi.nlm.nih.gov/pubmed/25420025 http://dx.doi.org/10.1371/journal.pone.0113865 |
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