Role of Ca(2+) and L-Phe in Regulating Functional Cooperativity of Disease-Associated “Toggle” Calcium-Sensing Receptor Mutations

The Ca(2+)-sensing receptor (CaSR) regulates Ca(2+) homeostasis in the body by monitoring extracellular levels of Ca(2+) ([Ca(2+)](o)) and amino acids. Mutations at the hinge region of the N-terminal Venus flytrap domain (VFTD) produce either receptor inactivation (L173P, P221Q) or activation (L173F...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Mulpuri, Nagaraju, Hannan, Fadil M., Nesbit, M. Andrew, Thakker, Rajesh V., Hamelberg, Donald, Brown, Edward M., Yang, Jenny J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242666/
https://www.ncbi.nlm.nih.gov/pubmed/25420019
http://dx.doi.org/10.1371/journal.pone.0113622

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