Cargando…

Stargazin promotes closure of the AMPA receptor ligand-binding domain

Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown. Here we find that the...

Descripción completa

Detalles Bibliográficos
Autores principales:	MacLean, David M., Ramaswamy, Swarna S., Du, Mei, Howe, James R., Jayaraman, Vasanthi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242809/ https://www.ncbi.nlm.nih.gov/pubmed/25422502 http://dx.doi.org/10.1085/jgp.201411287

Ejemplares similares

Structural landscape of the isolated ligand binding domain of single AMPA receptors
por: Landes, Christy F., et al.
Publicado: (2011)

Autoinactivation of the Stargazin–AMPA Receptor Complex: Subunit-Dependency and Independence from Physical Dissociation
por: Semenov, Artur, et al.
Publicado: (2012)

Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation
por: Brown, Patricia M.G.E., et al.
Publicado: (2018)

Stargazin and γ4 slow the channel opening and closing rates of GluA4 AMPA receptors
por: Pierce, Vincen D., et al.
Publicado: (2019)

Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation
por: Coombs, Ian D., et al.
Publicado: (2017)

Mechanism of modulation of AMPA receptors by TARP-γ8
por: Carrillo, Elisa, et al.
Publicado: (2019)

Activity-Mediated AMPA Receptor Remodeling, Driven by Alternative Splicing in the Ligand-Binding Domain
por: Penn, Andrew C., et al.
Publicado: (2012)

Conformational Selection and Submillisecond Dynamics of the Ligand-binding Domain of the N-Methyl-d-aspartate Receptor
por: Dolino, Drew M., et al.
Publicado: (2016)

A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc
por: Sirrieh, Rita E., et al.
Publicado: (2015)

Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses
por: Louros, Susana R., et al.
Publicado: (2018)

Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability
por: Caldeira, G. L., et al.
Publicado: (2022)

Domain Architecture of a Calcium-Permeable AMPA Receptor in a Ligand-Free Conformation
por: Midgett, Charles R., et al.
Publicado: (2012)

Reversible domain closure modulates GlnBP ligand binding affinity
por: Chen, Qun, et al.
Publicado: (2022)

Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects
por: Golubeva, Elena A., et al.
Publicado: (2022)

α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly
por: Li, Lingyong, et al.
Publicado: (2021)

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor
por: Vasilenko, Dmitry A., et al.
Publicado: (2021)

Modeling the binding of diverse ligands within the Ah receptor ligand binding domain
por: Giani Tagliabue, Sara, et al.
Publicado: (2019)

The structure-energy landscape of NMDA Receptor gating
por: Dolino, Drew M., et al.
Publicado: (2017)

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking
por: Bissen, Diane, et al.
Publicado: (2019)

Analysis of high-affinity assembly for AMPA receptor amino-terminal domains
por: Zhao, Huaying, et al.
Publicado: (2012)

Comparative Dynamics of NMDA- and AMPA-Glutamate Receptor N-Terminal Domains
por: Dutta, Anindita, et al.
Publicado: (2012)

Analysis of high-affinity assembly for AMPA receptor amino-terminal domains
por: Zhao, Huaying, et al.
Publicado: (2013)

Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains
por: Zhao, Huaying, et al.
Publicado: (2017)

The Transmembrane Domain C of AMPA Receptors is Critically Involved in Receptor Function and Modulation
por: Terhag, Jan, et al.
Publicado: (2010)

Computational Analysis on the Allostery of Tryptophan Synthase: Relationship between α/β-Ligand Binding and Distal Domain Closure
por: Ito, Shingo, et al.
Publicado: (2022)

Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum
por: Coombs, I.D., et al.
Publicado: (2009)

The small phytoplasma virulence effector SAP11 contains distinct domains required for nuclear targeting and CIN-TCP binding and destabilization
por: Sugio, Akiko, et al.
Publicado: (2014)

Ligand-Dependent Opening of the Multiple AMPA Receptor Conductance States: A Concerted Model
por: Dutta-Roy, Ranjita, et al.
Publicado: (2015)

Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors
por: Gonzalez, Cuauhtemoc U., et al.
Publicado: (2021)

Uncorking AMPA receptors
por: Sedwick, Caitlin
Publicado: (2018)

Resensitizing AMPA receptors
por: Short, Ben
Publicado: (2019)

Structure of the homodimeric androgen receptor ligand-binding domain
por: Nadal, Marta, et al.
Publicado: (2017)

Ligand Binding Induces Agonistic-Like Conformational Adaptations in Helix 12 of Progesterone Receptor Ligand Binding Domain
por: Zheng, Liangzhen, et al.
Publicado: (2019)

Molecular cloning of the gene promoter encoding the human Ca(V)γ(2)/Stargazin divergent transcript (CACNG2-DT): characterization and regulation by the cAMP-PKA/CREB signaling pathway
por: Muñoz-Herrera, David, et al.
Publicado: (2023)

Mechanistic Understanding of the Phosphorylation-Induced Conformational Rigidity at the AMPA Receptor C-terminal Domain
por: Chatterjee, Sudeshna, et al.
Publicado: (2019)

Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators
por: Dohrke, Jan-Niklas, et al.
Publicado: (2020)

A New Family of Macrocyclic Polyamino Biphenolic Ligands: Acid-Base Study, Zn(II) Coordination and Glyphosate/AMPA Binding
por: Giacomazzo, Gina Elena, et al.
Publicado: (2023)

AMPA Receptor Activation Causes Silencing of AMPA Receptor-Mediated Synaptic Transmission in the Developing Hippocampus
por: Wasling, Pontus, et al.
Publicado: (2012)

Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease
por: Gu, Xunhu, et al.
Publicado: (2021)

Phosphorylation of Spastin Promotes the Surface Delivery and Synaptic Function of AMPA Receptors
por: Chen, Li, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_klg1raljjv4fv2pt2kiho2h4kh