p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers

OBJECTIVE(S): Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Cons...

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Autores principales: Kalantari, Mahmoud Reza, Anvari, Kazem, Jabbari, Hasan, Tabrizi, Fatemeh Varshoee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242919/
https://www.ncbi.nlm.nih.gov/pubmed/25429340
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author Kalantari, Mahmoud Reza
Anvari, Kazem
Jabbari, Hasan
Tabrizi, Fatemeh Varshoee
author_facet Kalantari, Mahmoud Reza
Anvari, Kazem
Jabbari, Hasan
Tabrizi, Fatemeh Varshoee
author_sort Kalantari, Mahmoud Reza
collection PubMed
description OBJECTIVE(S): Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. MATERIALS AND METHODS: We studied 98 prostate biopsy blocks (40 adenocarcinoma and 58 benign lesions) for basal cell marker expression. RESULTS: p63 and 34βE12 were negative in all prostate adenocarcinoma specimens, but all benign prostate hyperplasia and high grade intraepithelial neoplasia cases expressed them. CONCLUSION: Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers.
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spelling pubmed-42429192014-11-26 p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers Kalantari, Mahmoud Reza Anvari, Kazem Jabbari, Hasan Tabrizi, Fatemeh Varshoee Iran J Basic Med Sci Original Article OBJECTIVE(S): Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in men after lung cancer. Differentiation of prostate adenocarcinoma from benign prostate lesions and hyperplasia sometimes cannot be done on the basis of morphologic findings. Considering the fact that in the prostate adenocarcinoma there is no basal cell layer, basal cell markers can help to differentiate prostate adenocarcinoma from cancer mimickers. MATERIALS AND METHODS: We studied 98 prostate biopsy blocks (40 adenocarcinoma and 58 benign lesions) for basal cell marker expression. RESULTS: p63 and 34βE12 were negative in all prostate adenocarcinoma specimens, but all benign prostate hyperplasia and high grade intraepithelial neoplasia cases expressed them. CONCLUSION: Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. Mashhad University of Medical Sciences 2014-07 /pmc/articles/PMC4242919/ /pubmed/25429340 Text en © Iranian Journal of Basic Medical Sciences This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kalantari, Mahmoud Reza
Anvari, Kazem
Jabbari, Hasan
Tabrizi, Fatemeh Varshoee
p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
title p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
title_full p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
title_fullStr p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
title_full_unstemmed p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
title_short p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers
title_sort p63 is more sensitive and specific than 34βe12 to differentiate adenocarcinoma of prostate from cancer mimickers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242919/
https://www.ncbi.nlm.nih.gov/pubmed/25429340
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