Spectrophotometric Estimation of Risperidone in Tablets

A simple, rapid and highly sensitive spectrophotometric method is developed for the determination of risperidone in tablet formulation. The method is based on the oxidation of drug using potassium permanganate in alkaline medium and excess potassium permanganate oxidizes 1,10-phenanthroline Fe(II)....

Descripción completa

Detalles Bibliográficos
Autores principales: Jayanna, B. K., Devaraj, T. D., Roopa, K. P., Nagendrappa, G., Kumar, H. R. Arun, Gowda, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243264/
https://www.ncbi.nlm.nih.gov/pubmed/25425761
_version_ 1782346079043321856
author Jayanna, B. K.
Devaraj, T. D.
Roopa, K. P.
Nagendrappa, G.
Kumar, H. R. Arun
Gowda, N.
author_facet Jayanna, B. K.
Devaraj, T. D.
Roopa, K. P.
Nagendrappa, G.
Kumar, H. R. Arun
Gowda, N.
author_sort Jayanna, B. K.
collection PubMed
description A simple, rapid and highly sensitive spectrophotometric method is developed for the determination of risperidone in tablet formulation. The method is based on the oxidation of drug using potassium permanganate in alkaline medium and excess potassium permanganate oxidizes 1,10-phenanthroline Fe(II). The measurement of decrease in absorbance of 1,10-phenanthroline Fe (II) was done at 415 nm. The beer's law is obeyed in the concentration range of 5.0 to 40.0 μg/ml and molar absorptivity is found to be 7.3932 × 10(4) l/mol/cm. The proposed method is well suited for the pharmaceutical formulations.
format Online
Article
Text
id pubmed-4243264
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-42432642014-11-25 Spectrophotometric Estimation of Risperidone in Tablets Jayanna, B. K. Devaraj, T. D. Roopa, K. P. Nagendrappa, G. Kumar, H. R. Arun Gowda, N. Indian J Pharm Sci Short Communication A simple, rapid and highly sensitive spectrophotometric method is developed for the determination of risperidone in tablet formulation. The method is based on the oxidation of drug using potassium permanganate in alkaline medium and excess potassium permanganate oxidizes 1,10-phenanthroline Fe(II). The measurement of decrease in absorbance of 1,10-phenanthroline Fe (II) was done at 415 nm. The beer's law is obeyed in the concentration range of 5.0 to 40.0 μg/ml and molar absorptivity is found to be 7.3932 × 10(4) l/mol/cm. The proposed method is well suited for the pharmaceutical formulations. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4243264/ /pubmed/25425761 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Jayanna, B. K.
Devaraj, T. D.
Roopa, K. P.
Nagendrappa, G.
Kumar, H. R. Arun
Gowda, N.
Spectrophotometric Estimation of Risperidone in Tablets
title Spectrophotometric Estimation of Risperidone in Tablets
title_full Spectrophotometric Estimation of Risperidone in Tablets
title_fullStr Spectrophotometric Estimation of Risperidone in Tablets
title_full_unstemmed Spectrophotometric Estimation of Risperidone in Tablets
title_short Spectrophotometric Estimation of Risperidone in Tablets
title_sort spectrophotometric estimation of risperidone in tablets
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243264/
https://www.ncbi.nlm.nih.gov/pubmed/25425761
work_keys_str_mv AT jayannabk spectrophotometricestimationofrisperidoneintablets
AT devarajtd spectrophotometricestimationofrisperidoneintablets
AT roopakp spectrophotometricestimationofrisperidoneintablets
AT nagendrappag spectrophotometricestimationofrisperidoneintablets
AT kumarhrarun spectrophotometricestimationofrisperidoneintablets
AT gowdan spectrophotometricestimationofrisperidoneintablets

Ejemplares similares