Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment

CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therape...

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Detalles Bibliográficos
Autores principales: Lawrenczyk, Agnieszka, Kim, Seil, Wen, Xiangshu, Xiong, Ran, Yuan, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243429/
https://www.ncbi.nlm.nih.gov/pubmed/25438012
http://dx.doi.org/10.3390/pathogens3030563
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author Lawrenczyk, Agnieszka
Kim, Seil
Wen, Xiangshu
Xiong, Ran
Yuan, Weiming
author_facet Lawrenczyk, Agnieszka
Kim, Seil
Wen, Xiangshu
Xiong, Ran
Yuan, Weiming
author_sort Lawrenczyk, Agnieszka
collection PubMed
description CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therapeutic target for anti-HBV treatment. We aim to humanize mice in the CD1d/iNKT cell lipid presentation system and provide new research tools for identifying novel anti-HBV agents.
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spelling pubmed-42434292014-11-25 Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment Lawrenczyk, Agnieszka Kim, Seil Wen, Xiangshu Xiong, Ran Yuan, Weiming Pathogens Review CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therapeutic target for anti-HBV treatment. We aim to humanize mice in the CD1d/iNKT cell lipid presentation system and provide new research tools for identifying novel anti-HBV agents. MDPI 2014-07-03 /pmc/articles/PMC4243429/ /pubmed/25438012 http://dx.doi.org/10.3390/pathogens3030563 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Lawrenczyk, Agnieszka
Kim, Seil
Wen, Xiangshu
Xiong, Ran
Yuan, Weiming
Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
title Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
title_full Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
title_fullStr Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
title_full_unstemmed Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
title_short Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
title_sort exploring the therapeutic potentials of inkt cells for anti-hbv treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243429/
https://www.ncbi.nlm.nih.gov/pubmed/25438012
http://dx.doi.org/10.3390/pathogens3030563
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