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Early Development of the Gut Microbiota and Immune Health
In recent years, the increase in human microbiome research brought about by the rapidly evolving “omic” technologies has established that the balance among the microbial groups present in the human gut, and their multipronged interactions with the host, are crucial for health. On the other hand, epi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243441/ https://www.ncbi.nlm.nih.gov/pubmed/25438024 http://dx.doi.org/10.3390/pathogens3030769 |
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author | Francino, M. Pilar |
author_facet | Francino, M. Pilar |
author_sort | Francino, M. Pilar |
collection | PubMed |
description | In recent years, the increase in human microbiome research brought about by the rapidly evolving “omic” technologies has established that the balance among the microbial groups present in the human gut, and their multipronged interactions with the host, are crucial for health. On the other hand, epidemiological and experimental support has also grown for the ‘early programming hypothesis’, according to which factors that act in utero and early in life program the risks for adverse health outcomes later on. The microbiota of the gut develops during infancy, in close interaction with immune development, and with extensive variability across individuals. It follows that the specific process of gut colonization and the microbe-host interactions established in an individual during this period have the potential to represent main determinants of life-long propensity to immune disease. Although much remains to be learnt on the progression of events by which the gut microbiota becomes established and initiates its intimate relationships with the host, and on the long-term repercussions of this process, recent works have advanced significatively in this direction. |
format | Online Article Text |
id | pubmed-4243441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42434412014-11-25 Early Development of the Gut Microbiota and Immune Health Francino, M. Pilar Pathogens Review In recent years, the increase in human microbiome research brought about by the rapidly evolving “omic” technologies has established that the balance among the microbial groups present in the human gut, and their multipronged interactions with the host, are crucial for health. On the other hand, epidemiological and experimental support has also grown for the ‘early programming hypothesis’, according to which factors that act in utero and early in life program the risks for adverse health outcomes later on. The microbiota of the gut develops during infancy, in close interaction with immune development, and with extensive variability across individuals. It follows that the specific process of gut colonization and the microbe-host interactions established in an individual during this period have the potential to represent main determinants of life-long propensity to immune disease. Although much remains to be learnt on the progression of events by which the gut microbiota becomes established and initiates its intimate relationships with the host, and on the long-term repercussions of this process, recent works have advanced significatively in this direction. MDPI 2014-09-24 /pmc/articles/PMC4243441/ /pubmed/25438024 http://dx.doi.org/10.3390/pathogens3030769 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Francino, M. Pilar Early Development of the Gut Microbiota and Immune Health |
title | Early Development of the Gut Microbiota and Immune Health |
title_full | Early Development of the Gut Microbiota and Immune Health |
title_fullStr | Early Development of the Gut Microbiota and Immune Health |
title_full_unstemmed | Early Development of the Gut Microbiota and Immune Health |
title_short | Early Development of the Gut Microbiota and Immune Health |
title_sort | early development of the gut microbiota and immune health |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243441/ https://www.ncbi.nlm.nih.gov/pubmed/25438024 http://dx.doi.org/10.3390/pathogens3030769 |
work_keys_str_mv | AT francinompilar earlydevelopmentofthegutmicrobiotaandimmunehealth |