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Large-scale Mutational Analysis of Kv11.1 Reveals Molecular Insights into Type 2 Long QT Syndrome

It has been suggested that deficient protein trafficking to the cell membrane is the dominant mechanism associated with type 2 Long QT syndrome (LQT2) caused by Kv11.1 potassium channel missense mutations, and that for many mutations the trafficking defect can be corrected pharmacologically. However...

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Detalles Bibliográficos
Autores principales:	Anderson, Corey L., Kuzmicki, Catherine E., Childs, Ryan R., Hintz, Caleb J., Delisle, Brian P., January, Craig T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243539/ https://www.ncbi.nlm.nih.gov/pubmed/25417810 http://dx.doi.org/10.1038/ncomms6535

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