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Increased Putamen Volume in Adults with Autism Spectrum Disorder

Basal ganglia (BG) abnormalities are implicated in the pathophysiology of autism spectrum disorder (ASD). However, studies measuring the volume of the entire BG in individuals with ASD have reported discrepant findings, and no study conducted volume measurement of the entire substructures of the BG...

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Autores principales: Sato, Wataru, Kubota, Yasutaka, Kochiyama, Takanori, Uono, Shota, Yoshimura, Sayaka, Sawada, Reiko, Sakihama, Morimitsu, Toichi, Motomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243557/
https://www.ncbi.nlm.nih.gov/pubmed/25505401
http://dx.doi.org/10.3389/fnhum.2014.00957
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author Sato, Wataru
Kubota, Yasutaka
Kochiyama, Takanori
Uono, Shota
Yoshimura, Sayaka
Sawada, Reiko
Sakihama, Morimitsu
Toichi, Motomi
author_facet Sato, Wataru
Kubota, Yasutaka
Kochiyama, Takanori
Uono, Shota
Yoshimura, Sayaka
Sawada, Reiko
Sakihama, Morimitsu
Toichi, Motomi
author_sort Sato, Wataru
collection PubMed
description Basal ganglia (BG) abnormalities are implicated in the pathophysiology of autism spectrum disorder (ASD). However, studies measuring the volume of the entire BG in individuals with ASD have reported discrepant findings, and no study conducted volume measurement of the entire substructures of the BG (the caudate, putamen, nucleus accumbens, and globus pallidus) in individuals with ASD. We delineated the BG substructures and measured their volumes in 29 adults with ASD without intellectual disabilities and 29 age- and gender-matched typically developed adult controls. We acquired T1-weighted anatomical images and performed semiautomated delineation and volume measurements of the above-mentioned subregions. Total cerebral volumes, sex, and ages were partialed out. Compared with controls, the putamen was significantly larger in the ASD group. The increased volume of the putamen found in high-functioning adults with ASD suggests that structural or histological abnormalities of the putamen may underlie the pathologies of ASD, such as repetitive and stereotyped behaviors and impaired social interactions.
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spelling pubmed-42435572014-12-10 Increased Putamen Volume in Adults with Autism Spectrum Disorder Sato, Wataru Kubota, Yasutaka Kochiyama, Takanori Uono, Shota Yoshimura, Sayaka Sawada, Reiko Sakihama, Morimitsu Toichi, Motomi Front Hum Neurosci Neuroscience Basal ganglia (BG) abnormalities are implicated in the pathophysiology of autism spectrum disorder (ASD). However, studies measuring the volume of the entire BG in individuals with ASD have reported discrepant findings, and no study conducted volume measurement of the entire substructures of the BG (the caudate, putamen, nucleus accumbens, and globus pallidus) in individuals with ASD. We delineated the BG substructures and measured their volumes in 29 adults with ASD without intellectual disabilities and 29 age- and gender-matched typically developed adult controls. We acquired T1-weighted anatomical images and performed semiautomated delineation and volume measurements of the above-mentioned subregions. Total cerebral volumes, sex, and ages were partialed out. Compared with controls, the putamen was significantly larger in the ASD group. The increased volume of the putamen found in high-functioning adults with ASD suggests that structural or histological abnormalities of the putamen may underlie the pathologies of ASD, such as repetitive and stereotyped behaviors and impaired social interactions. Frontiers Media S.A. 2014-11-25 /pmc/articles/PMC4243557/ /pubmed/25505401 http://dx.doi.org/10.3389/fnhum.2014.00957 Text en Copyright © 2014 Sato, Kubota, Kochiyama, Uono, Yoshimura, Sawada, Sakihama and Toichi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sato, Wataru
Kubota, Yasutaka
Kochiyama, Takanori
Uono, Shota
Yoshimura, Sayaka
Sawada, Reiko
Sakihama, Morimitsu
Toichi, Motomi
Increased Putamen Volume in Adults with Autism Spectrum Disorder
title Increased Putamen Volume in Adults with Autism Spectrum Disorder
title_full Increased Putamen Volume in Adults with Autism Spectrum Disorder
title_fullStr Increased Putamen Volume in Adults with Autism Spectrum Disorder
title_full_unstemmed Increased Putamen Volume in Adults with Autism Spectrum Disorder
title_short Increased Putamen Volume in Adults with Autism Spectrum Disorder
title_sort increased putamen volume in adults with autism spectrum disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243557/
https://www.ncbi.nlm.nih.gov/pubmed/25505401
http://dx.doi.org/10.3389/fnhum.2014.00957
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