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Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work
Lactate, the conjugate base of lactic acid occurring in aqueous biological fluids, has been derided as a “dead-end” waste product of anaerobic metabolism. Catalyzed by the near-equilibrium enzyme lactate dehydrogenase (LDH), the reduction of pyruvate to lactate is thought to serve to regenerate the...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243568/ https://www.ncbi.nlm.nih.gov/pubmed/25505376 http://dx.doi.org/10.3389/fnins.2014.00366 |